Toxicogenomics using yeast DNA microarrays

Journal of Bioscience and Bioengineering
Daisuke Yasokawa, Hitoshi Iwahashi

Abstract

Development of genomics and bioinformatics enable us to analyze the global gene expression profiles of cells by DNA microarray. Changes in gene expression patterns indicate changes in its physiological conditions. Following the exposure of an organism or cell to toxic chemicals or other environmental stresses, the global genetic responses can be expeditiously and easily analyzed. Baker's yeast, Saccharomyces cerevisiae, is one of the most studied and useful model eukaryotes. The biggest advantage of yeast genomics is the available functional information for each gene and a considerable number of data are accumulating in the field of toxicity assessment using yeast DNA microarray. In this review, we discuss the toxicogenomics of metal ions, alcohols and aldehydes, and other chemicals.

References

Jul 1, 1976·Mutation Research·R J Wilkins, H D Macleod
Jan 1, 1990·Critical Reviews in Toxicology·H D HeckT B Starr
Jul 1, 1988·Mutation Research·T H Ma, M M Harris
Jul 1, 1995·Mutation Research·N P Singh, A Khan
Jan 1, 1995·Critical Reviews in Biotechnology·G J Salter, D B Kell
Jun 1, 1995·Journal of Industrial Microbiology·A Vaughan-Martini, A Martini
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·A P Schmitt, K McEntee
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S A Jelinsky, L D Samson
Apr 16, 1999·Molecular Carcinogenesis·E F NuwaysirC A Afshari
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·J S HardwickS L Schreiber
Apr 25, 2000·Journal of Toxicology. Clinical Toxicology·S M BradberryJ A Vale
Dec 5, 2000·Molecular Biology of the Cell·A P GaschP O Brown
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·James A FlemingRonald K Blackman
May 15, 2002·Bioscience, Biotechnology, and Biochemistry·Sakiko KuritaHitoshi Iwahashi
Jun 1, 2002·The Journal of Antimicrobial Chemotherapy·Liang ZhangJing Cheng
Jun 12, 2002·The Journal of Biological Chemistry·Hiroyuki YoshimotoMartha S Cyert
Jul 26, 2002·Nature·Guri GiaeverMark Johnston
Sep 25, 2002·Environmental Science & Technology·Emiko KitagawaHitoshi Iwahashi
Jan 25, 2003·Journal of Industrial Microbiology & Biotechnology·Weiwen ZhangJeffrey R Shuster
May 29, 2003·The Journal of Biological Chemistry·Yoshinori MurataHitoshi Iwahashi
Aug 5, 2003·Canadian Journal of Microbiology·Eduardo V SoaresHelena M V M Soares
Oct 17, 2003·Nature·Won-Ki HuhErin K O'Shea
Nov 25, 2003·Water Research·Sophon SirisatthaHitoshi Iwahashi
Jun 18, 2004·The Journal of Antimicrobial Chemotherapy·Meher ParveenHitoshi Iwahashi
Feb 17, 2005·Molecular and Cellular Biology·A Lucau-DanilaC Jacq
Sep 6, 2005·Differentiation; Research in Biological Diversity·Jana SmardováJana Koptíková
Oct 29, 2005·Extremophiles : Life Under Extreme Conditions·Yoshinori MurataHitoshi Iwahashi
Dec 27, 2005·Bioscience, Biotechnology, and Biochemistry·Emiko KitagawaHitoshi Iwahashi
Mar 2, 2006·Journal of Agricultural and Food Chemistry·Yumiko IwahashiHitoshi Iwahashi
May 20, 2006·Yeast·Susannah HoranBrigitte Meunier
May 25, 2006·Chemistry & Biology·Gilbert T KellyCoran M H Watanabe
Jul 28, 2006·Antimicrobial Agents and Chemotherapy·Veronika SimonsAnne Osbourn

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Citations

Mar 31, 2015·Current Opinion in Biotechnology·Sandra C dos Santos, Isabel Sá-Correia
Nov 20, 2012·Molecular Plant Pathology·Hans J Cools, Kim E Hammond-Kosack
Dec 6, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jolanda S van LeeuwenJ Chris Vos
Sep 3, 2013·FEMS Yeast Research·Gökhan KüçükgözeZ Petek Çakar
Jun 3, 2017·Biomolecular Concepts·Myriam LazardPierre Plateau
May 26, 2020·GigaScience·Angela SerraDario Greco
Apr 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Roger M PallaresRebecca J Abergel

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