PMID: 6162434Jul 1, 1980Paper

Toxicokinetic and toxicodynamic studies of beryllium

Archives of Toxicology
T StiefelG Tölg

Abstract

The question of dose-effect relations of berylliosis was examined by measuring the Be-concentration in blood and urine, as well as the immunological behaviour of T-lymphocytes for a group of occupationally exposed men (smaller than 8 ng Be/m3, 4-6 h daily) and a non-exposed control group. Normal values 1.0 +/- 0.4 ng Be/g(n=10) in blood and 0.9 +/- 0.5 ng Be/g(n=10) in urine were found by an optimized flameless atomic absorption spectrometry method. The corresponding values for the exposed group (n=8) showed a mean increase of a factor of 4. The preferential enrichment of Be in the prealbumin and in the nu-globulin fractions was determined by a preparative isotachophoretic column with physiological pH conditions, especially developed for this application. The Be-specific stimulation of the T-lymphocytes of the exposed group was increased significantly. In blood and urine samples of exposed (2-40 mg Be/m3 as Be(NO3)2) Wistar-rats and guinea pigs Be values up to 36 ng Be/g in serum and up to 300 ng Be/g in urine were determined. After Be exposure, guinea pig serum showed a significant increase in the nu-globulins after the isotachophoretical separation of the serum proteins, which could not be correlated with increased Be-levels ...Continue Reading

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Citations

Oct 22, 2010·International Archives of Occupational and Environmental Health·Jackie MortonJohn Cocker
Jul 1, 1987·Mutation Research·A Léonard, R Lauwerys
Oct 1, 1993·Environmental Health Perspectives·A Léonard, A Bernard
Mar 1, 1990·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·J Ramaker, W G Wood
Aug 8, 2009·Reviews on Environmental Health·T Mark McCleskeyBrian L Scott
Apr 14, 2010·Indian Journal of Occupational and Environmental Medicine·Ross G Cooper, Adrian P Harrison
Jan 1, 1993·Critical Reviews in Toxicology·J J HostýnekR H Guy
Oct 21, 2011·International Journal of Toxicology·Caroline MullerJoseph Zayed
Aug 1, 1995·Alcoholism, Clinical and Experimental Research·C L EhlersM A Schuckit
Dec 21, 2018·Journal of Occupational and Environmental Hygiene·Jérôme DevoyDavy Rousset
Dec 1, 1992·Ergonomics·R T Wilkinson
Jan 1, 2013·3 Biotech·Stephen Juma Mulware

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