Toxicokinetic-toxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power.

Ecotoxicology
Anna-Maija NymanRoman Ashauer

Abstract

Toxicokinetic-toxicodynamic (TKTD) models quantify the time-course of internal concentration, which is defined by uptake, elimination and biotransformation (TK), and the processes which lead to the toxic effects (TD). TKTD models show potential in predicting pesticide effects in fluctuating concentrations, but the data requirements and validity of underlying model assumptions are not known. We calibrated TKTD models to predict survival of Gammarus pulex in propiconazole exposure and investigated the data requirements. In order to assess the need of TK in survival models, we included or excluded simulated internal concentrations based on pre-calibrated TK. Adding TK did not improve goodness of fits. Moreover, different types of calibration data could be used to model survival, which might affect model parameterization. We used two types of data for calibration: acute toxicity (standard LC50, 4 d) or pulsed toxicity data (total length 10 d). The calibration data set influenced how well the survival in the other exposure scenario was predicted (acute to pulsed scenario or vice versa). We also tested two contrasting assumptions in ecotoxicology: stochastic death and individual tolerance distribution. Neither assumption fitted to da...Continue Reading

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Citations

Apr 25, 2014·Environmental Science & Technology·Anna-Maija NymanRoman Ashauer
Oct 1, 2015·Environmental Toxicology and Chemistry·Lam Ngoc TracAnnemette Palmqvist
Apr 3, 2015·Integrated Environmental Assessment and Management·Virginie DucrotGabriel Weyman
Jul 16, 2015·Environmental Science & Technology·Roman AshauerBeate I Escher
Jan 15, 2014·The Journal of Animal Ecology·André Gergs, Tjalling Jager
Apr 25, 2013·Integrated Environmental Assessment and Management·Valery E Forbes, Peter Calow
Apr 9, 2013·Integrated Environmental Assessment and Management·Roman Ashauer, Colin D Brown
Feb 1, 2013·Environmental Toxicology and Chemistry·Roman AshauerSteve Maund
Aug 21, 2013·Environmental Toxicology and Chemistry·Masoud M Ardestani, Cornelis A M van Gestel
Apr 18, 2015·British Journal of Pharmacology·Tarjinder SahotaOscar Della Pasqua
Nov 28, 2013·Critical Reviews in Toxicology·Janice E ChambersGlen Van Der Kraak
May 28, 2016·Environmental Science & Technology·Andrea RöschJuliane Hollender
Jul 7, 2016·Scientific Reports·Roman AshauerThomas G Preuss
Jan 7, 2017·PLoS Computational Biology·Pia Abel Zur WieschTed Cohen
Feb 9, 2017·Environmental Science & Technology·Roman AshauerBeate I Escher
Mar 9, 2017·Environmental Science & Technology·Marie Laure Delignette-MullerPhilippe Veber
Mar 25, 2018·Integrated Environmental Assessment and Management·Tjalling Jager, Roman Ashauer
May 22, 2018·Integrated Environmental Assessment and Management·Virgile BaudrotSandrine Charles
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Nov 26, 2015·Science Advances·Julita Stadnicka-MichalakRoman Ashauer
Aug 23, 2018·EFSA Journal·UNKNOWN EFSA Panel on Plant Protection Products and their Residues (PPR)Ivana Teodorovic
Nov 2, 2019·Chemical Research in Toxicology·Thomas MartinRoman Ashauer
Sep 19, 2017·Environmental Science & Technology·Andrea RöschJuliane Hollender
Mar 6, 2019·Environmental Science & Technology·Jochen P ZubrodRalf B Schäfer
Sep 10, 2020·Environmental Science & Technology·Maricor J ArlosChristian Stamm

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Methods Mentioned

BETA
MDA
chemical stress

Software Mentioned

GraphPad Prism
ModelMaker
TRACE
GraphPad
GUTS

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