Abstract
This paper reviews the toxicokinetics of amphetamines. The designer drugs MDA (methylenedioxy-amphetamine, R,S-1-(3;,4;-methylenedioxyphenyl)2-propanamine), MDMA (R,S-methylenedioxymethamphetamine), and MDE (R,S-methylenedioxyethylamphetamine), as well as BDB (benzodioxolylbutanamine; R,S-1-(1;,3;-benzodioxol-5;-yl)-2-butanamine or R,S-1-(3;,4;-methylenedioxyphenyl)-2-butanamine) and MBDB (R,S-N-methyl-benzodioxolylbutanamine), were taken into consideration, as were the following N-alkylated amphetamine derivatives: amphetaminil, benzphetamine, clobenzorex, dimethylamphetamine, ethylamphetamine, famprofazone, fencamine, fenethylline, fenproporex, furfenorex, mefenorex, mesocarb, methamphetamine, prenylamine, and selegiline. English-language publications from 1995 to 2000 were reviewed. Papers describing identification of metabolites or cytochrome P450 isoenzyme-dependent metabolism and papers containing pharmacokinetic/toxicokinetic data were considered and summarized. The implications of toxicokinetics for toxicologic assessment or for interpretation in forensic cases are discussed.
References
Jan 1, 1992·Archives of Toxicology·H H Maurer, T Kraemer
Nov 1, 1991·Biological Mass Spectrometry·H K Lim, R L Foltz
Nov 1, 1991·Chemical Research in Toxicology·H K Lim, R L Foltz
Sep 1, 1990·Journal of Analytical Toxicology·D E MoodyM Y Law
Jan 26, 1990·Journal of Chromatography·H M Liebich, C Först
Oct 1, 1986·Journal of Psychoactive Drugs·D E Nichols
Nov 1, 1988·Chemical Research in Toxicology·H K Lim, R L Foltz
Aug 1, 1995·British Journal of Pharmacology·M I ColadoA R Green
Mar 29, 1994·Biochemical Pharmacology·G T TuckerT Y Chu
May 1, 1994·Chemical Research in Toxicology·J M GraceT L Macdonald
Mar 22, 1996·Biochemical Pharmacology·T ChuA K Cho
Jul 12, 1996·Forensic Science International : Synergy·J T Cody
Oct 1, 1995·Biopharmaceutics & Drug Disposition·I MahmoodW D Mason
Aug 1, 1996·Therapeutic Drug Monitoring·H H Maurer
Sep 1, 1996·Chemical Research in Toxicology·F CarvalhoM L Bastos
Oct 1, 1996·Journal of Analytical Toxicology·J T Cody, S Valtier
Oct 1, 1996·Journal of Analytical Toxicology·H J HelmlinR Brenneisen
Aug 30, 1996·Journal of Chromatography. B, Biomedical Applications·H K EnsslinH H Maurer
Nov 1, 1996·Journal of Analytical Toxicology·G W KunsmanM L Smith
Feb 7, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·H H MaurerA A Weber
Feb 1, 1997·The Journal of Toxicological Sciences·H YamadaH Yoshimura
Jan 1, 1997·Chirality·H S Shin
Apr 1, 1997·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S ShiiyamaH Yoshimura
Aug 1, 1997·Clinical Pharmacokinetics·I Mahmood
Jun 1, 1997·Biochemical Pharmacology·D WuE M Sellers
Nov 5, 1997·Journal of Analytical Toxicology·J T Cody, S Valtier
Nov 5, 1997·Pharmacology, Biochemistry, and Behavior·S Y Yeh
Dec 17, 1997·Journal of Analytical Toxicology·P Kintz
Dec 17, 1997·Journal of Analytical Toxicology·M R Moeller, M Hartung
Dec 31, 1997·Biomedical Chromatography : BMC·M NeugebauerG Saleh
Feb 4, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·T KraemerH H Maurer
Jul 29, 1998·Journal of Analytical Toxicology·J T Cody, S Valtier
Aug 13, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·M R MoellerT Kraemer
Aug 13, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·T Kraemer, H H Maurer
Oct 27, 1998·Journal of Analytical Toxicology·A PoklisA Costantino
Nov 3, 1998·Clinical Pharmacology and Therapeutics·H ScheininL Bertilsson
Nov 24, 1998·International Journal of Legal Medicine·F Musshoff, T Kraemer
Dec 30, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·M BrunnenbergK A Kovar
Jan 23, 1999·Journal of Chromatography. a·C Gunaratna, P T Kissinger
Feb 24, 1999·Lancet·M SchwabE U Griese
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·K M HegadorenM Bourin
Apr 1, 1999·Human & Experimental Toxicology·A Walubo, D Seger
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·A L Jones, K J Simpson
Jun 16, 1999·Journal of Analytical Toxicology·J T CodyS Stillman
Jun 17, 1999·Forensic Science International : Synergy·M HasegawaK Kimura
Aug 24, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M V BachG B Baker
Oct 12, 1999·Journal of Analytical Toxicology·K L BadenJ T Cody
Nov 26, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·P Kintz, N Samyn
Dec 14, 1999·Journal of Analytical Toxicology·J T Cody, S Valtier
Feb 15, 2000·British Journal of Clinical Pharmacology·R de la TorreJ Camí
Citations
Jan 11, 2005·Neurotoxicity Research·H G Baumgarten, L Lachenmayer
Mar 7, 2012·Archives of Toxicology·Márcia CarvalhoMaria de Lourdes Bastos
May 1, 2007·Analytical and Bioanalytical Chemistry·Thomas Kraemer, Liane D Paul
Apr 12, 2011·Analytical and Bioanalytical Chemistry·K DeventerP Van Eenoo
Aug 26, 2011·Analytical and Bioanalytical Chemistry·Markus R Meyer, Hans H Maurer
Jul 26, 2011·International Journal of Legal Medicine·Evelyn PawlikThomas Daldrup
Aug 31, 2013·Biochemical Pharmacology·Golo M J MeyerHans H Maurer
Feb 6, 2004·European Journal of Pharmacology·Liane D PaulHans H Maurer
Apr 20, 2013·Forensic Science International : Synergy·Kuan-Fu ChenCheng-Huang Lin
Jul 7, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Annis MechanGeorge A Ricaurte
Sep 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rodney J IrvineJason M White
Dec 17, 2009·Journal of Psychoactive Drugs·Shinobu Watanabe-GallowayA Cate Malone
Oct 31, 2009·Journal of Analytical Toxicology·Tsadik T AbrahamMarilyn A Huestis
Oct 2, 2003·Clinical Neuropharmacology·Louise MartinssonStaffan Eksborg
Jun 4, 2008·Therapeutic Drug Monitoring·Erin A KolbrichMarilyn A Huestis
Aug 24, 2011·Therapeutic Drug Monitoring·Allan J BarnesMarilyn A Huestis
Jul 16, 2008·Journal of Clinical Psychopharmacology·Erin A KolbrichMarilyn A Huestis
Nov 2, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·F Garcia-BournissenG Koren
Mar 24, 2011·Molecular Neurodegeneration·P M Abdul MuneerJames Haorah
Feb 12, 2004·Clinical Pharmacokinetics·Rafael de la TorreSimona Pichini
Feb 22, 2011·Pharmacogenomics·Markus R Meyer, Hans H Maurer
Oct 29, 2011·Genetics and Molecular Research : GMR·L DongD Yu
Apr 26, 2006·International Journal of Legal Medicine·Els A De LetterMichel H A Piette
Nov 26, 2013·Psychological Medicine·F J van der MeerE Velthorst
Nov 21, 2014·Bioanalysis·Anders Just PedersenWolfgang Weinmann
Mar 15, 2012·Expert Opinion on Drug Metabolism & Toxicology·Sophie DuongSharon B Wigal
Nov 25, 2014·Archives of Toxicology·Julia DingerHans H Maurer
Jul 16, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D SpringerH H Maurer
Feb 6, 2003·Rapid Communications in Mass Spectrometry : RCM·Nieves PizarroRafael de la Torre
Jan 21, 2016·Addiction·Marie Claire Van Hout, John Wells
Sep 4, 2015·Therapeutic Drug Monitoring·Jessica Welter-Luedeke, Hans H Maurer
Aug 4, 2012·Journal of Chromatography. a·Andrea E SchwaningerHans H Maurer
Mar 27, 2012·Psychiatry Research·Kyongsik YunJaeseung Jeong
Dec 15, 2015·Drugs & Aging·David W GoodmanCraig B H Surman
Oct 11, 2011·Biochemical Pharmacology·Andrea E SchwaningerHans H Maurer
Sep 11, 2010·Forensic Science International : Synergy·Frank MusshoffBurkhard Madea
Jul 6, 2010·The Science of the Total Environment·Alexander L N van NuijsAdrian Covaci
Dec 1, 2015·Water Research·Ann-Kathrin McCallChristoph Ort
Jul 7, 2009·Toxicology Letters·Markus R MeyerHans H Maurer
Dec 17, 2008·Forensic Science International : Synergy·Adriaan A S Marais, Johannes B Laurens
Jan 8, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jenny-Ann PhanAlbert Gjedde
Apr 22, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Tamsin KellyMarilyn A Huestis
Jul 7, 2007·Forensic Science International : Synergy·Kenji KuwayamaTohru Kishi
Jun 19, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Roland F StaackBurkhard Rolf
Sep 2, 2004·British Journal of Pharmacology·Zaid A AbassiMoussa B H Youdim
Jul 26, 2005·Journal of Mass Spectrometry : JMS·Denis S TheobaldHans H Maurer
May 12, 2009·Addiction·Christopher C Cruickshank, Kyle R Dyer
Jun 27, 2003·Journal of Mass Spectrometry : JMS·Frank T PetersHans H Maurer
Mar 7, 2003·Rapid Communications in Mass Spectrometry : RCM·Hans-Jörg LeisWerner Windischhofer
Oct 20, 2006·Journal of Mass Spectrometry : JMS·Hans H Maurer