PMID: 2116687Jul 1, 1990Paper

Toxicokinetics of monochloroacetic acid: a whole-body autoradiography study

Toxicology
H K BhatG A Ansari

Abstract

Monochloroacetic acid (MCA) is a toxic chemical used as a herbicide and in the synthesis of various organic compounds. MCA has also been shown to be present in chlorinated drinking waters. In order to understand the mechanism of MCA toxicity, we studied the tissue distribution of [1-14C]MCA in rats, by whole-body autoradiographic technique. Male Sprague-Dawley rats were given a tracer dose of [1-14C]MCA [6.8 micrograms/100 g (40 mu Ci) body weight] by tail vein and euthanized at different time intervals (5 min, 1, 4, 12, 24 and 48 h). The animals were embedded in carboxymethyl cellulose and frozen immediately. Frozen animals were sectioned and processed using whole-body autoradiographic techniques. Analysis of developed sections showed that at 5 min, there was a rapid accumulation of 14C-activity in the kidney cortex and stomach walls. The radioactivity was rapidly removed from the circulation. There was high accumulation of 14C-activity in the myocardial tissues. The liver was also loaded with MCA and/or its metabolites. After 1 h following administration of [14C]MCA, radioactivity was extensively excreted into the small intestinal lumen. the accumulation of 14C-activity in the brain, thymus, salivary glands and tongue was pro...Continue Reading

References

Jan 1, 1989·Journal of Biochemical Toxicology·H K Bhat, G A Ansari
Oct 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M R BerardiK R Cooper
Sep 1, 1973·Toxicology and Applied Pharmacology·F D HayesJ E Gibson
Jan 1, 1971·Acta Pharmacologica Et Toxicologica·S Yllner
Jan 1, 1971·Acta Pharmacologica Et Toxicologica·S Yllner
Jan 1, 1971·Acta Pharmacologica Et Toxicologica·S Yllner
Aug 13, 1983·The Veterinary Record·M P QuickJ F Bolton
Jan 1, 1961·Acta Pharmacologica Et Toxicologica·M CHRISTIANSEN, S DALGAARDO-MIKKELSEN

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