Abstract
To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit suicide and arrived at our hospital early, not later than 7 h after PQ ingestion. The urine dithionite test for PQ in all of the nine patients was strongly positive at emergency room. Blood samples were obtained every 30 min for the first 2~3 h and then every 1 or 2 h, as long as the clinical progression was stable among the patients for 30 h after PQ ingestion. The area under the plasma concentration-time curve (AUCinf), which was extrapolated to infinity, was calculated using the trapezoidal rule. Toxicokinetic parameters, such as the terminal elimination half-life, apparent oral clearance, and apparent volume of distribution (Vd/F) were calculated. The maximum PQ concentration (Cmax) and the time to reach maximum PQ concentration (Tmax) were also obtained. Plasma PQ concentrations in nine patients were well described by a bi-exponential curve with a mean terminal elimination half-life of 13.1±6.8 h. Cmax and AUCinf were 20.8±25.7 mg/l and 172.5±160.3 h·mg/l, respectively. Apparent volume of distribution and apparent oral clearance were 50.9±61.3 l/kg and ...Continue Reading
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Citations
Apr 12, 2018·Medicine·Narcisse ElengaMonique Mathieu-Nolf
Apr 17, 2019·Experimental and Therapeutic Medicine·Honggang ChenXiaoyan Fu
Dec 30, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy AndersonDeborah A Cory-Slechta
Sep 17, 2021·The Journal of International Medical Research·Yu-Quan ChenYi-Min Liu
Nov 16, 2021·Therapeutic Drug Monitoring·Yahui TangZhongqiu Lu