Toxicokinetics of perfluorooctane sulfonate in rainbow trout (Oncorhynchus mykiss)

Environmental Toxicology and Chemistry
Daniel M ConsoerJ W Nichols

Abstract

Rainbow trout (Oncorhynchus mykiss) confined to respirometer-metabolism chambers were dosed with perfluorooctane sulfonate (PFOS) by intra-arterial injection and sampled to obtain concentration time-course data for plasma and either urine or expired water. The data were then analyzed using a 2-compartment clearance-volume model. Renal and branchial clearance rates (mL/d/kg) determined for all experiments averaged 19% and 81% of total clearance, respectively. Expressed as mean values for all experiments, the steady-state volume of distribution was 277 mL/kg and the terminal half-life was 86.8 d. Additional animals were exposed to PFOS in water, resulting in an average calculated branchial uptake efficiency of 0.36%. The renal clearance rate determined in the present study is approximately 75 times lower than that determined in earlier studies with perfluorooctanoate (PFOA). Previously, it was suggested that PFOA is a substrate for membrane transporters in the trout kidney. The present study suggests that glomerular filtration may be sufficient to explain the observed renal clearance rate for PFOS, although a role for membrane transporters cannot be ruled out. These findings demonstrate that models developed to predict the bioacc...Continue Reading

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Citations

Dec 20, 2016·Environmental Toxicology and Chemistry·James M ArmitageJohn W Nichols
Apr 14, 2019·Environmental Science and Pollution Research International·Alice VidalMarc Babut
Nov 18, 2020·Environmental Toxicology and Chemistry·Amila O De SilvaElsie M Sunderland
Mar 24, 2018·Chemosphere·Vinit K Mittal, Carla A Ng
Mar 13, 2021·The Science of the Total Environment·Adam D PointBernard S Crimmins
Nov 18, 2021·Environmental Science. Processes & Impacts·Steven T J DrogeGeoff Hodges

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