Toxicokinetics of propylene glycol mono-t-butyl ether following intravenous or inhalation exposure in rats and mice

Inhalation Toxicology
Jeffrey DillJoseph Roycroft

Abstract

Propylene glycol mono-t-butyl ether (PGMBE) is a widely used solvent in industry and in consumer products, posing a potential for human exposure via inhalation or dermal routes. Toxicokinetic studies were conducted on F344/N rats and B6C3F1 mice of both sexes to evaluate single or repeated dose, species, and/or sex differences in PGMBE elimination kinetics following intravenous or inhalation exposure. In the first study, rats and mice received a single intravenous dose of 15 or 200 mg PGMBE/kg and serial blood samples were collected and analyzed for PGMBE. In the second study, rats and mice received a single 6-h whole-body inhalation exposure to 75, 300, or 1200 ppm PGMBE and serial blood samples were collected and analyzed for PGMBE. In the third study, rats and mice received whole-body inhalation exposures to 75, 300, or 1200 ppm PGMBE for 6 h/day, 5 days/wk for 14 (rats) or 16 (mice) wk. Serial blood samples were analyzed for PGMBE after 2, 6, 14 (rats), and 16 (mice) wk on study. Urine samples were also collected for 16 h postexposure and analyzed for creatinine and PGMBE sulfate and PGMBE glucuronide conjugates. These studies revealed that: (1) PGMBE was eliminated from blood following concentration-dependent nonlinear kin...Continue Reading

References

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Citations

Aug 2, 2008·Clinical and Experimental Pharmacology & Physiology·Kathleen A StringerRajiv Nayar
Oct 4, 2005·Expert Opinion on Pharmacotherapy·Udaya S TantryPaul A Gurbel
Mar 7, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mi Ho JeongKyu Hyuck Chung

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