Toxicokinetics, Tissue Distribution, and Excretion of Dufulin Racemate and Its R ( S)-Enantiomers in Rats

Journal of Agricultural and Food Chemistry
Huaguo ChenBaoan Song

Abstract

Dufulin is a plant antiviral agent with a novel molecular structure and has been used widely to prevent and control tobacco and rice viral diseases. In this study, an UHPLC-MS/MS method was developed for rapid determination of dufulin racemate ( rac-DFL) and its R ( S)-enantiomers in rat plasma, tissues, urine, and feces. A MALDI-MSI method was further used for visual research on tissue distribution after intragastric administration of the three analytes. Toxicokinetic study showed that both ( R)-enantiomer of dufulin (( R)-DFL) and ( S)-enantiomer of dufulin (( S)-DFL) had a faster ability to reach Cmax than that of rac-DFL. ( R)-DFL and ( S)-DFL had a similar T1/2, though both were significantly lower than rac-DFL. Cmax of rac-DFL was obviously higher than ( R)-DFL or ( S)-DFL. Meanwhile, Cmax of ( S)-DFL was only about 60% of ( R)-DFL. Rac-DFL and its R ( S)-enantiomers had a dose-dependent toxicokinetic profile. Tissue distribution results revealed rac-DFL, ( R)-DFL, and ( S)-DFL mainly distributed in the liver and kidney, but the maximum concentration was only ng/g grade and could significantly degrade within 3 h. This indicates that dufulin does not cause liver and kidney toxicity in animals. In addition, rac-DFL and its ...Continue Reading

References

Dec 11, 2013·Environmental Science and Pollution Research International·Hua Zi WangHong Yang
Feb 12, 2014·Journal of Agricultural and Food Chemistry·Kan-Kan ZhangBao-An Song
Apr 8, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yongxue SunBinghu Fang
May 3, 2015·Bioorganic & Medicinal Chemistry·Xiangyang LiBaoan Song
Dec 25, 2015·Methods in Molecular Biology·Birte BeineCorinna Henkel
Aug 11, 2017·Journal of Agricultural and Food Chemistry·Shiau-Han JiangTung-Hu Tsai
Aug 11, 2017·Journal of Agricultural and Food Chemistry·Mengmeng TongRuyan Hou
Aug 13, 2017·Journal of the American Society for Mass Spectrometry·Bryn FlindersRon M A Heeren
Aug 24, 2017·Chemosphere·Alexandrine RobertThomas Knigge
Mar 6, 2018·Regulatory Toxicology and Pharmacology : RTP·Deeksha BhartiyaRavi Mehrotra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.