Toxicologic effect and transcriptome analysis for short-term orally dosed enrofloxacin combined with two veterinary antimicrobials on rat liver.

Ecotoxicology and Environmental Safety
Yehui LuanLinli Cheng

Abstract

Presently, toxicological assessment of multiple veterinary antimicrobials has not been performed on mammals. In this study, we assessed the short-term toxicity of enrofloxacin (E) combined with colistin (C) and quinocetone (Q). Young male rats were orally dosed drug mixtures and single drugs in 14 consecutive days, each at the dose of 20, 80, and 400 mg/(kg·BW) for environmental toxicologic study. The results showed that at the high dose treatment, the combination of E + C+Q significantly decreased body intake, lymphocytes count on rats; significantly increased the values of Alanine aminotransferase (ALT), Glutamic oxaloacetic transaminase (AST) and, cholinesterase (CHE); it also got the severest histopathological changes, where sinusoidal congestion and a large number of black particles in sinusoids were observed. This means E + C+Q in the high dose groups was able to cause significant damage to the liver. Other combinations or doses did not induce significant liver damage. Transcriptome analysis was then performed on rats in high dose group for further research. For E + C and E + Q, an amount of 375 and 480 differently expressed genes were filtered out, revealing their possible underlying effect on genomes. For E + C+Q, a wei...Continue Reading

References

Nov 1, 1995·Acta Physiologica Scandinavica·G T EspersenN Grunnet
Jan 22, 2005·Molecular Endocrinology·Megumi EndoTetsuya Kamataki
Mar 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Matthew E Falagas, Sofia K Kasiakou
Feb 23, 2008·Toxicology·Josef OzerShelli Schomaker
Dec 9, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qian ChenXilong Xiao
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Jul 1, 2010·The Journal of Antimicrobial Chemotherapy·Kari GraveDavid Mackay
Aug 18, 2010·Regulatory Toxicology and Pharmacology : RTP·Xu WangZong-Hui Yuan
Aug 24, 2012·The Journal of Antimicrobial Chemotherapy·Kari GraveUNKNOWN ESVAC Group
Jan 8, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Guiping YuanXinghong Zhao
Apr 18, 2014·Journal of Pharmacological Sciences·Ling-ling JiaXiao-dong Liu
Feb 18, 2015·Veterinary Research Communications·Chrząstek Klaudia, Wieliczko Alina
Mar 10, 2015·Nature Methods·Daehwan KimSteven L Salzberg
Mar 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Thomas P Van BoeckelRamanan Laxminarayan
Oct 22, 2015·Expert Review of Anti-infective Therapy·Yiying CaiAndrea L Kwa
Jan 27, 2017·Current Drug Targets·Palrasu Manikandan, Siddavaram Nagini
Apr 19, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammad RaishAbdullah M Al-Mohizea
Dec 5, 2017·Research in Veterinary Science·Yinsheng LiJiangping Qiu
Dec 13, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Xiayun YangXilong Xiao
Apr 2, 2019·Developmental Biology·Tetiana PetrachkovaDonald A Kane
Feb 10, 2020·The Science of the Total Environment·Wenhui QiuChunmiao Zheng
Sep 6, 2020·Ecotoxicology and Environmental Safety·Marcelo Pedrosa GomesPhilippe Juneau

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