PMID: 9191872May 1, 1997Paper

Toxicological and immunological evaluation of the MHC-non-restricted cytotoxic T cell line TALL-104

Cancer Immunology, Immunotherapy : CII
A CesanoD Santoli

Abstract

The human MHC-non-restricted cytotoxic T cell line TALL-104 has been shown to display potent antitumor effects in several animal models with spontaneous and induced malignancies. In view of its potential future use in cancer therapy, we investigated the tolerability and target-organ toxicity of these cells in various animal species. The acute toxicity of TALL-104 cell administrations was evaluated in: (a) healthy immunocompetent mice and immunodeficient (SCID) mice bearing human tumors using multiple (up to 15) intraperitoneal (i.p.) injections, and (b) healthy dogs, tumor-bearing dogs, and healthy monkeys using multiple (up to 17) intravenous (i.v.) injections. TALL-104 cells were gamma-irradiated (40 Gy) prior to administration to mice and dogs, but administered without irradiation in monkeys. Cell doses ranged from 5 x 10(7)/kg to 10(10)/kg for each injection. All regimens were well tolerated, the main clinical signs observed being transient gastrointestinal effects. Moderate and transient increases in liver transaminase levels were observed in all animal species. Discrete and transient leukocytosis with neutrophilia was also noted in dogs and monkeys after i.v. injections of TALL-104 cells. Histological analysis revealed fo...Continue Reading

Citations

Mar 31, 1988·Biochimica Et Biophysica Acta·C M Thomas
Mar 18, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Chunsheng LiuKah-Whye Peng

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