Toxicological and pathophysiological roles of reactive oxygen and nitrogen species.

Toxicology
Ruth A RobertsFredika M Robertson

Abstract

'Oxidative and Nitrative Stress in Toxicology and Disease' was the subject of a symposium held at the EUROTOX meeting in Dresden 15th September 2009. Reactive oxygen (ROS) and reactive nitrogen species (RNS) produced during tissue pathogenesis and in response to viral or chemical toxicants, induce a complex series of downstream adaptive and reparative events driven by the associated oxidative and nitrative stress. As highlighted by all the speakers, ROS and RNS can promote diverse biological responses associated with a spectrum of disorders including neurodegenerative/neuropsychiatric and cardiovascular diseases. Similar pathways are implicated during the process of liver and skin carcinogenesis. Mechanistically, reactive oxygen and nitrogen species drive sustained cell proliferation, cell death including both apoptosis and necrosis, formation of nuclear and mitochondrial DNA mutations, and in some cases stimulation of a pro-angiogenic environment. Here we illustrate the pivotal role played by oxidative and nitrative stress in cell death, inflammation and pain and its consequences for toxicology and disease pathogenesis. Examples are presented from five different perspectives ranging from in vitro model systems through to in vi...Continue Reading

References

Aug 1, 1987·Journal of Molecular and Cellular Cardiology·P K SingalL E Weinberg
Feb 1, 1974·Annals of Internal Medicine·R H Blum, S K Carter
Apr 1, 1983·Environmental Health Perspectives·S M Cohen
Jul 16, 1981·The New England Journal of Medicine·R C YoungC E Myers
Dec 23, 1993·Nature·M Radman, R Wagner
May 26, 1998·Journal of Neuropathology and Experimental Neurology·P F GoodC W Olanow
Jul 22, 1998·The Journal of Experimental Medicine·Y NakamotoF V Chisari
Sep 24, 1998·The New England Journal of Medicine·P K Singal, N Iliskovic
Feb 13, 2001·BMJ : British Medical Journal·S D Ryder, I J Beckingham
Mar 7, 2001·Antioxidants & Redox Signaling·I RusynR G Thurman
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·P PacherC Szabó
Aug 24, 2002·Pharmacology & Toxicology·Jason D Oliver, Ruth A Roberts
Jul 26, 2003·Antioxidants & Redox Signaling·Manuchair Ebadi, Sushil K Sharma
Aug 28, 2003·Brain Research. Molecular Brain Research·Robert A SmithSheng T Hou
Sep 1, 2004·Cell and Tissue Research·Peter Teismann, Jörg B Schulz
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Ruth DjaldettiEldad Melamed
Feb 16, 2005·Biochemical Pharmacology·Orsolya SzencziTamás Ivanics
Feb 18, 2005·Journal of Neurochemistry·Manus W WardChristopher N Connolly
Jun 6, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christine L PowellIvan Rusyn
Nov 24, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ruth A RobertsJames E Klaunig
Feb 17, 2007·Neuroscience·E Trushina, C T McMurray
Aug 2, 2007·Nature Reviews. Drug Discovery·Csaba SzabóRafael Radi
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Malú G TanseyThi A Tran
May 21, 2008·Free Radical Biology & Medicine·Mutay AslanIclal Yucel
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Amos Akintayo FatokunRobert Anthony Smith

❮ Previous
Next ❯

Citations

Dec 18, 2013·International Journal of Hygiene and Environmental Health·Iman Al-SalehAbdullah Rabbah
Feb 14, 2014·Neuromolecular Medicine·Georgia S Gaki, Athanasios G Papavassiliou
Apr 14, 2012·Journal of Amino Acids·Volodymyr I Lushchak
Dec 1, 2010·Archives of Pharmacal Research·Hyoung Jin KimSoon Ha Kim
May 11, 2013·Biological Trace Element Research·Iman Al-SalehNeptune Shinwari
Dec 4, 2012·Antioxidants & Redox Signaling·Lirija AliliPeter Brenneisen
Nov 12, 2015·Biomolecules·Muna Sapkota, Todd A Wyatt
Oct 8, 2013·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Martha R Herbert, Cindy Sage
Sep 13, 2014·Oxidative Medicine and Cellular Longevity·María MuriachJorge M Barcia
Apr 10, 2012·Clinical Biochemistry·Ignazio GrattaglianoPiero Portincasa
Nov 9, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Pilar Codoñer-FranchEulalia Alonso-Iglesias
Mar 19, 2011·Toxicology·Klaudia Jomova, Marian Valko
Mar 9, 2011·Cancer Letters·Jeremy J Johnson
Nov 28, 2015·Critical Reviews in Toxicology·James P Kehrer, Lars-Oliver Klotz
Feb 26, 2011·EMBO Reports·Benjamin EzratySam Dukan
Apr 30, 2014·Journal of Applied Toxicology : JAT·Varun Ahuja, Sharad Sharma
Mar 19, 2014·Journal of Pineal Research·Alejandro RomeroRussel J Reiter
Dec 10, 2014·Journal of Manipulative and Physiological Therapeutics·Carolina KolbergWania A Partata
Sep 10, 2014·International Journal of Cosmetic Science·M NadimC Grillon
Mar 30, 2013·Biochemical and Biophysical Research Communications·Katalin MódisCsaba Szabo
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Mustafa VarçinSophie Sarre
Jun 12, 2012·The Science of the Total Environment·Iman Al-SalehRola Elkhatib
Feb 4, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·John M PrinsKathleen M George
Feb 22, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Shuyan LuYvonne Will
May 29, 2012·Mutation Research·Marie Z Vasquez
Sep 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu-Hsiang KuanYu-Chao Chang
Apr 9, 2014·Neuroscience and Biobehavioral Reviews·Byron K Y Bitanihirwe, Tsung-Ung W Woo
Feb 19, 2011·Mutation Research·Jean CadetJean-Luc Ravanat
Jun 29, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·A P LanY Hu
Jul 9, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·William DeCoteauJoseph S Erlichman
Oct 31, 2016·International Journal of Hygiene and Environmental Health·Iman Al-SalehMichael Nester
Apr 3, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Xinyu WangYiyun Cheng
Dec 19, 2016·The International Journal of Biochemistry & Cell Biology·Aleksandar PantovicLjubica Harhaji-Trajkovic

❮ Previous
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