Toxicological approaches to the toxic metabolites of Fusaria. VIII. Acute and subacute toxicities of T-2 toxin in cats.

Japanese Journal of Pharmacology
N SatoM Enomoto

Abstract

Acute and subacute toxicities to cats of T-2 toxin, 12-13 epoxytrichothec mycotoxin from fungi Fusarium species and others, were investigated. Major symptoms of toxicity in cats as the result of T-2 toxin were emesis, vomiting, diarrhea, anorexia, ataxia of the hind legs, discharge from the eyes and ejection of hemorrhagic fluid. Consecutive administration of the crude and pure sample of T-2 toxin in a sublethal dose caused a marked decrease in the number of circulating white blood cells. In the early stage of intoxication, a temporal leukocytosis was observed after each administration. Autopsy revealed extensive cellular damages in the bone marrow, intestine, spleen and lymph nodes. Greatly evident were meningeal hemorrhage of the brain, bleeding in the lungs and vacuolic degeneration of the renal tubles. Mycotoxicological significance of T-2 toxin and related trichothecenes is discussed in relation to the food-borne diseases in humans and farm animals.

Citations

Oct 1, 1985·Archives of Toxicology·F BergmannD Soffer
Jan 1, 1982·Avian Pathology : Journal of the W.V.P.A·F J HoerrA Z Joffe
Feb 1, 1992·Pharmacology & Toxicology·U SirkkaP Ylitalo
Sep 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K OhtsuboY Ueno
Mar 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R GuntherC J Mirocha
May 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R S TomarW E DeCoteau
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·F J Plasencia, Y Rosenstein
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·J C RyuY Ueno
Jan 1, 1987·Toxicology·S FairhurstD W Swanston
Jan 1, 1986·International Journal of Immunopharmacology·R S TomarW E DeCoteau
May 1, 1989·Archives of Environmental Contamination and Toxicology·P P Williams
Dec 1, 1978·Food and Cosmetics Toxicology·D B DeNicolaB Yagen
Jun 30, 1983·Toxicology and Applied Pharmacology·S C FriendH B Schiefer
May 1, 1984·Toxicology and Applied Pharmacology·P K Chan, P A Gentry
Mar 15, 1991·Toxicology and Applied Pharmacology·H L BorisonD C Thut
May 10, 2015·Neurotoxicology·Bruno LebrunMichel Dallaporta
Sep 3, 2004·Toxicology Letters·D Parent-Massin
Jun 1, 1980·Food and Cosmetics Toxicology·C RukminiK Rao
Dec 1, 1989·Toxicology and Applied Pharmacology·H L Borison, M L Goodheart
Feb 1, 1984·Toxicology and Applied Pharmacology·S C LeeF S Chu
Apr 1, 1986·Environmental Health Perspectives·W G SorensonV Castranova
Jan 1, 1985·Critical Reviews in Toxicology·Y Ueno
Jan 1, 1988·Immunopharmacology and Immunotoxicology·P S HoltJ R DeLoach
Aug 1, 1982·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·P Rafai, S Tuboly
Oct 28, 1998·Toxicologic Pathology·J ShinozukaK Doi
Aug 19, 1988·Biochimica Et Biophysica Acta·P S Holt, J R DeLoach
Oct 12, 2021·International Journal of Biological Macromolecules·Wei YeWeimin Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.