Toxicological assessment of biological pesticides

Toxicology Letters
I C Dewhurst

Abstract

The majority of pesticides are based on synthetic chemicals. Regulatory assessments are performed by comparing the findings in a range of routine toxicity studies, designed for testing chemicals, with estimates of exposures. Recently there have been significant moves towards developing natural/biological alternatives. Biological pesticides (those based on viable organisms) present the regulator with a different set of challenges to those raised by most chemical pesticides. The concerns associated with biological pesticides can vary greatly from one organism to another, requiring an almost case-by-case approach. The known toxicity of certain bio-molecules and the pathogenicity of certain organisms underlines the need for a risk assessment of biological pesticides. The main aspects of a health risk assessment are characterisation of the organism, infectivity, pathogenicity, sensitisation and production of toxic secondary metabolites. Obtaining information or data on these areas is not always easy as there are no widely accepted test schemes or protocols for organisms, though guidelines are being developed for the European Commission (EC). Predicting exposure following pesticidal use of an organism is made more complex if it multi...Continue Reading

Citations

May 4, 2007·Bulletin of Environmental Contamination and Toxicology·Haifeng QianYingchong Lu
Jan 18, 2007·Environmental Monitoring and Assessment·Haifeng QianTao Hong
Dec 1, 2003·Nutrition Research Reviews·Faidon MagkosAntonis Zampelas
Jan 13, 2006·Critical Reviews in Food Science and Nutrition·Faidon MagkosAntonis Zampelas
Jun 3, 2016·Frontiers in Microbiology·Sana RomdhaneFabrice Martin-Laurent
Sep 16, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G A KleterH J P Marvin

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