Toxicological Assessment of CoO and La2O3 Metal Oxide Nanoparticles in Human Small Airway Epithelial Cells

Toxicological Sciences : an Official Journal of the Society of Toxicology
Jennifer D SislerYong Qian

Abstract

Cobalt monoxide (CoO) and lanthanum oxide (La2O3) nanoparticles are 2 metal oxide nanoparticles with different redox potentials according to their semiconductor properties. By utilizing these two nanoparticles, this study sought to determine how metal oxide nanoparticle's mode of toxicological action is related to their physio-chemical properties in human small airway epithelial cells (SAEC). We investigated cellular toxicity, production of superoxide radicals and alterations in gene expression related to oxidative stress, and cellular death at 6 and 24 h following exposure to CoO and La2O3(administered doses: 0, 5, 25, and 50 µg/ml) nanoparticles. CoO nanoparticles induced gene expression related to oxidative stress at 6 h. After characterizing the nanoparticles, transmission electron microscope analysis showed SAEC engulfed CoO and La2O3nanoparticles. CoO nanoparticles were toxic after 6 and 24 h of exposure to 25.0 and 50.0 µg/ml administered doses, whereas, La2O3nanoparticles were toxic only after 24 h using the same administered doses. Based upon the Volumetric Centrifugation Methodin vivoSedimentation, Diffusion, and Dosimetry, the dose of CoO and La2O3nanoparticles delivered at 6 and 24 h were determined to be: CoO: 1.25...Continue Reading

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Citations

Sep 21, 2017·Toxicologic Pathology·Robert R MercerAnn F Hubbs
Aug 4, 2020·The Journal of Toxicological Sciences·Lu YuanXiujun Zhang
Mar 7, 2020·Environmental Science. Nano·Glen M DeLoidPhilip Demokritou
Jul 9, 2018·ACS Biomaterials Science & Engineering·Priyanka GangulySuresh C Pillai
Sep 2, 2021·The Science of the Total Environment·Sudisha JogaiahMuthusamy Govarthanan

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