PMID: 11313113Apr 21, 2001Paper

Toxicological consequences of toxaphene ingestion by cynomolgus (Macaca fascicularis) monkeys. Part 1: pre-mating phase

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D L ArnoldS Fernie

Abstract

A total of 40 menstruating cynomolgus monkeys (Macaca fascicularis) with an average age of 7.25 +/- 1.06 years (standard deviation), five male cynomolgus monkeys with an average age of 12.6 +/- 0.66 years, and five male cynomolgus males with an average age of 6.2 +/- 0.23 years were obtained from the Health Canada breeding laboratory. The females were initially randomized to the four test groups in accordance with their previous reproductive success and body weight. They were then randomly allocated between two similar environmentally-controlled rooms (20 females/room). The males were randomly assigned to one of the test rooms (six or four males/room). The female test groups self-ingested capsules containing doses of 0, 0.1, 0.4 or 0.8 mg (Groups A, B, C, D) of technical grade toxaphene/kg body weight/day (i.e. five females/dose group/room). The older males (Group E) were proven breeders and were used exclusively for mating and their capsules contained no toxaphene. The younger males (Group F) ingested capsules containing 0.8 mg of technical grade toxaphene/kg body weight/day. After 20 weeks of daily dosing, it was assumed, based on the results of a pilot study [Andrews P., Headrick K., Pilon J.-C., Bryce F., Iverson F. (1996) ...Continue Reading

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Citations

Aug 11, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H TryphonasS Hayward
Dec 14, 2011·Integrated Environmental Assessment and Management·Pim E G LeonardsJacob de Boer
Nov 22, 2005·The Science of the Total Environment·J Van OostdamS Kalhok

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