Toxicological Effects of Cadmium on Mammalian Testis

Frontiers in Genetics
Qiqi ZhuRen-Shan Ge

Abstract

Cadmium is a heavy metal, and people are exposed to it through contaminated foods and smoking. In humans and other mammals, cadmium causes damage to male testis. In this review, we summarize the effects of cadmium on the development and function of the testis. Cadmium causes severe structural damage to the seminiferous tubules, Sertoli cells, and blood-testis barrier, thus leading to the loss of sperm. Cadmium hinders Leydig cell development, inhibits Leydig cell function, and induces Leydig cell tumors. Cadmium also disrupts the vascular system of the testis. Cadmium is a reactive oxygen species inducer and possibly induces DNA damage, thus epigenetically regulating somatic cell and germ cell function, leading to male subfertility/infertility.

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Citations

Jan 24, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wesley N SaintilnordYvonne N Fondufe-Mittendorf
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Jacopo Junio Valerio BrancaMatteo Becatti
Nov 28, 2020·Toxicology Letters·Aleksandra Popov AleksandrovMilena Kataranovski
Aug 4, 2021·Toxicon : Official Journal of the International Society on Toxinology·Xiaoyi LiuHongbo Hu
Nov 19, 2021·Journal of Biochemical and Molecular Toxicology·Eman A A Abdallah, Mohamed F El-Refaei

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