PMID: 6407928Jun 1, 1983Paper

Toxicological evaluation in rats and mice of the ingestion of a cheese made from milk with added formaldehyde

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
C L GalliM Marinovich

Abstract

Male Swiss albino mice (CD-1) and male Sprague-Dawley rats were given single oral doses of 0.5 g (4.0 microCi) and 2.2 g (18 microCi) 14C-labelled grana cheese, respectively. The cheese was made by the normal process but using milk with added [14C]formaldehyde. The plasma and tissue kinetics of the radiolabelled cheese were studied by monitoring the decay of radioactivity in the plasma, gastrointestinal tract, liver, kidney, lung, testes, spleen, brain, muscle and adipose tissue. The faeces and urine of animals placed in individual metabolism cages were collected between 4 and 64 hr after dosing for rats and between 2 hr and 12 days for mice. Within 32 hr of administration 63-67% of the radioactivity had been excreted in the faeces and urine and 24-28% of the radioactivity had been exhaled as 14CO2, in both species. Maximum concentrations, corresponding to 0.07% and 0.3% of the dose per ml of blood were reached respectively within 8 hr for rats and 2 hr for mice. The toxicokinetic profile appears to be similar in mice and rats because of the similarity of the half-lives of the elimination phase, 27.8 and 26.4 hr respectively, and suggests that accumulation of the 14C-activity does not occur in any of the tissues of either speci...Continue Reading

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Citations

May 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P RestaniC L Galli
Sep 6, 2005·Environmental Health Perspectives·Vincent James CoglianoUNKNOWN Working Group for Volume 88
Dec 1, 1984·Environmental Health Perspectives
Jul 1, 2008·Toxicology Letters·Corrado Lodovico GalliMarcello Lotti
Jun 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·W KrauseW Schunack
Jan 1, 1991·Critical Reviews in Toxicology·P Restani, C L Galli

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