Toxicological evaluation of an Allium-based commercial product in a 90-day feeding study in Sprague-Dawley rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
P Mellado-GarcíaAna María Cameán

Abstract

Proallium AP(®) is a commercial Allium extract intended to be used in active food packaging as the antibacterial and antioxidant effects of some organosulfur compounds are well known. However, there is little information on its toxicity and the Scientific Committee on Food (UE) requires the safety assessment of substances used in food contact materials. Thus, the aim of this study was to conduct for the first time a subchronic oral toxicity study of Proallium AP(®) with groups of 10 males and 10 females Sprague-Dawley rats fed a diet containing 0, 25, 100, 400 mg/kg/d for 90 days. No treatment-related clinical signs or mortality were noted. Besides, no treatment-related effects with regard to any of the toxicological biomarkers considered were observed, including biochemical, haematological and histopathology parameters. In conclusion, the non-observed-adverse-effect-level (NOAEL) for Proallium AP(®) in rats was determined to be a dietary dose of 400 mg/kg/d under the present experimental conditions, a value 500-fold higher than the exposure derived from its potential use in active packaging.

References

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Apr 22, 2015·Journal of the Science of Food and Agriculture·Seung Yuan LeeSun Jin Hur
May 11, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María Llana-Ruiz-CabelloAna María Cameán
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Citations

Apr 18, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Pilar Mellado-GarcíaAna M Cameán
Mar 15, 2018·Journal of Toxicology and Environmental Health. Part a·María Llana-Ruiz-CabelloAna M Cameán
Aug 28, 2020·Frontiers in Immunology·Samanta C FunesAlexis M Kalergis
Mar 21, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Leticia Díez-QuijadaÁngeles Jos
Aug 2, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Antonio Cascajosa LiraAna M Cameán

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