PMID: 20650063Feb 1, 1995Paper

Toxicological evaluation of saxitoxin, neosaxitoxin, gonyautoxin II, gonyautoxin II plus III and decarbamoylsaxitoxin with the mouse neuroblastoma cell bioassay

Toxicology in Vitro : an International Journal Published in Association with BIBRA
J F JellettM V Laycock

Abstract

Four major paralytic shellfish poisoning (PSP) toxins in pure form-saxitoxin (STX), neosaxitoxin (NEO), gonyautoxin II (GTX II), and decarbamoylsaxitoxin (dcSTX), and mixed gonyautoxin II plus III (GTX II/III)-were toxicologically evaluated in the neuroblastoma cell bioassay and compared with the United States Food and Drug Administration standard reference saxitoxin (FDA STX). Mean relative toxicities of these experimental preparations were 99.5 (STX), 128.0 (NEO), 48.4 (GTX II) and 42.6 (dcSTX) when compared with FDA STX set arbitrarily at 100. Two mixtures of GTX II/III with relative concentrations of 1:2.5 and 4:1 had percentage relative toxicities of 52.4 and 54.5, respectively. Except for GTX II/III, which increased in toxicity, the toxicities of the experimental toxin preparations were not affected by boiling for 5 min in equal volumes of either 0.1 or 1.0 N HCl. Detailed examinations of dose-responses of each individual toxin preparation in the cell bioassay revealed some differences in response profiles. The toxicological data presented here support and extend previous information collected with the mouse bioassay and HPLC. The EC(50) values of STX and GTX II/III obtained under different conditions of matrix (acetic ac...Continue Reading

References

Apr 12, 1991·Journal of Chromatography·P ThibaultM V Laycock
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·K KogureR R Colwell
Nov 1, 1981·Journal of Agricultural and Food Chemistry·A A Genenah, Y Shimizu

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Citations

Jan 27, 2010·Analytical and Bioanalytical Chemistry·A R HumpageS M Froscio
Apr 15, 2004·Chemosphere·Laurence S David, Russell A Nicholson
Aug 15, 2002·Toxicon : Official Journal of the International Society on Toxinology·Russell A NicholsonDavid Graham
Feb 3, 2009·Journal of Toxicology and Environmental Health. Part a·Suzanne M FroscioAndrew R Humpage
Feb 23, 2011·Ecotoxicology and Environmental Safety·François PerreaultWilliam Gerson Matias
Sep 2, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A CaillaudJ Diogène
Oct 6, 2015·Journal of Toxicology and Environmental Health. Part a·Silvia P MelegariWilliam G Matias
Dec 2, 2009·Environmental Toxicology·Catherine BernardLarelle Fabbro
Mar 24, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ambbar Aballay-GonzalezAllisson Astuya
Dec 23, 2008·Toxicon : Official Journal of the International Society on Toxinology·Aurélie LedreuxCécile Bernard
Sep 9, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Marcia BoderoArjen Gerssen
May 16, 2006·Chemical Research in Toxicology·Lyndon E Llewellyn
Nov 6, 2010·Environmental Science & Technology·Arash ZamyadiMichèle Prévost
Apr 16, 2019·ACS Chemical Biology·April L LukowskiAlison R H Narayan

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