Toxicological evaluation of the natural products and some semisynthetic derivatives of Heterotheca inuloides Cass (Asteraceae)

Journal of Ethnopharmacology
José Luis Rodríguez-ChávezGuillermo Delgado

Abstract

Heterotheca ineuloides Cass (Asteraceae), popularly known as árnica mexicana, is widely used in Mexican traditional medicine to treat bruises, dermatological problems, rheumatic pains, and other disorders as cancer. The major constituents in H. inuloides are cadinane type sesquiterpenes, flavonoids and phytosterols. Compounds with a cadinane skeleton have been proved to possess cytotoxic activity against human-tumor cell lines and brine shrimp, and display toxic effects in different animal species. Although this plant has been widely used, there is little available information on the safety and toxicity especially of pure compounds. Evaluate the potential toxicity of the natural products isolated from H. inuloides and some semisynthetic derivatives. The toxic aspects of the following natural products isolated from dried flowers of H. inuloides: 7-hydroxy-3,4-dihydrocadalene (1), 7-hydroxycadalene (2), 3,7-dihydroxy-3(4H)-isocadalen-4-one (3), (1R,4R)-1-hydroxy-4H-1,2,3,4- tetrahydrocadalen-15-oic acid (4), D-chiro-inositol (5), quercetin (6), quercetin-3,7,3'-trimethyl ether (7), quercetin-3,7,3',4'-tetramethyl ether (8), eriodictyol-7,4'-dimethyl ether (9), α-spinasterol (10), caryolan-1,9β-diol (11) and 7-(3,3-dimethylallylox...Continue Reading

References

Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y P KeepersH M Pinedo
Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Nov 1, 1986·Journal of Ethnopharmacology·M Winkelman
Jun 1, 1994·Planta medica·I KuboT Ogura
Jun 1, 1993·Planta medica·P N SolisJ D Phillipson
Jan 1, 1997·Journal of Natural Products·K HeJ L McLaughlin
Apr 26, 2005·Biotechnology Advances·Jian ZhaoRobert Verpoorte
May 10, 2005·The Proceedings of the Nutrition Society·Glenn Iason
Mar 25, 2006·Phytotherapy Research : PTR·Lane JohnsonArt Martinez
Nov 15, 2006·Journal of Ethnopharmacology·Myrna Déciga-CamposRachel Mata
Jan 19, 2007·Journal of Medicinal Chemistry·Lucia BiasuttoCristina Paradisi
May 1, 1982·Planta medica·B N MeyerJ L McLaughlin
Apr 5, 2007·Nature Protocols·Vanicha Vichai, Kanyawim Kirtikara
Sep 25, 2007·Bioorganic & Medicinal Chemistry Letters·Hyang Yeon LeeSeung Bum Park
Nov 27, 2007·Toxicology and Applied Pharmacology·Lourdes Rodriguez-FragosoEliseo Torres
Jul 14, 2010·Toxicology·Elvia Coballase-UrrutiaJ Javier Espinosa-Aguirre
Dec 15, 2010·Journal of Ethnopharmacology·Angel Josabad Alonso-CastroAlejandro Garcia-Carranca
Jul 21, 2011·Journal of Pharmacology & Pharmacotherapeutics·S Parasuraman
Oct 2, 2013·International Journal of Toxicology·Prapapan PimkaewPawinee Piyachaturawat
Oct 24, 2014·Scientific Reports·Nancy J Ruiz-PérezJavier J Espinosa-Aguirre

❮ Previous
Next ❯

Citations

Sep 15, 2016·International Journal of Molecular Sciences·J Saúl García-PérezRoberto Parra-Saldivar
Sep 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guilin ChenMingquan Guo
Jul 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Flora Didii SaleriMingquan Guo
May 6, 2020·Journal of Toxicology and Environmental Health. Part a·Fernanda MajoloMárcia Inês Goettert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.