Toxicological investigations on the methanol sub-fraction of the seeds of Carica papaya as a male contraceptive in albino rats

Reproductive Toxicology
Nirmal K LohiyaShipra Garg

Abstract

Pre-clinical acute and sub-chronic toxicity studies of the methanol sub-fraction (MSF) of the seeds of Carica papaya, a putative male contraceptive, have been investigated in rats to evaluate safety of the test substance. A single oral dose of MSF at 2000 mg/kg body weight was studied over 14 days for acute toxicity, and daily oral doses of 50, 100, 250 and 500 mg/kg body weight were studied for 28- and 90-day periods for sub-chronic toxicity. Body weight, food and water intake and phenotypical toxicological symptoms were recorded daily. Sperm analysis, hematology, serum clinical biochemistry, libido and pathological examination of vital organs were recorded at the termination of the experimental periods. We observed no overt general toxicity in exposed animals. Food and water intake showed daily fluctuations within control limits. Sperm density showed a significant decrease in all 28- and 90-day repeated dose treated animals whereas total sperm motility inhibition was observed at 250 and 500 mg/kg dose levels at the 28-day time interval but in all dose groups at the 90-day interval. The preliminary results suggest the test substance may be a safe approach to male anti-fertility.

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Citations

Jul 6, 2011·Applied Biochemistry and Biotechnology·Lin HuangHe-Qing Huang
May 13, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nor Suhada AnuarMohammad Tariqur Rahman
May 8, 2016·Journal of Ethnopharmacology·Ashutosh SharmaMaría Luisa Villarreal
Sep 30, 2016·Andrologia·N K LohiyaA S Ansari
Jul 29, 2009·International Journal of Toxicology·J Joshua AllanAmit Agarwal
Apr 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adlin AfzanZakiah Ismail
Sep 3, 2013·Asian Pacific Journal of Tropical Biomedicine·Sinhalagoda Lekamlage Chandi Asoka DharmarathnaSenanayake Abeysinghe Mudiyanselage Kularatne

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