Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder

Toxicology Reports
Jung-Ho NohKyoung-Sik Moon

Abstract

White-spotted flower chafer (Protaetia brevitarsis) is an edible insect and its larva was used as a traditional Asian medicine. It's a promising material as a novel food source because of its nutritional components. In this study, as part of the preclinical toxicity program, we evaluated the toxicity of freeze-dried P. brevitarsis larva powder to develop a novel food material. In a single-dose oral toxicity study in rats, there were no changes in mortality, clinical observations, and body weight in rats administered 5000 mg/kg P. brevitarsis larva powder. In a 13-week oral repeated dose toxicity study in rats, there were no adverse effects or changes in mortality, clinical observations, body weight, food consumption, ophthalmology, clinical pathology, necropsy, organ weight, and histopathology at doses of 300, 1000, and 3000 mg/kg/day. In identification of allergic reactions, P. brevitarsis larva powder induced no increases of serum immunoglobulin E and histamine concentrations over 13 weeks of oral administration in rats. In a genotoxicity assessment, P. brevitarsis larva powder didn't provoke bacterial reverse mutations, chromosomal aberrations, and micronucleated reticulocytes. Therefore, freeze-dried P. brevitarsis larva po...Continue Reading

Citations

Jan 25, 2020·Journal of Food Science·Masaru OchiaiSeiya Horiguchi
Feb 6, 2020·Toxicology Reports·Kimberly J OngJo Anne Shatkin

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
chromosomal aberrations
chromosomal aberration

Software Mentioned

STAT
SAS

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