Toxicological significance of covalently-bound residues

Food Additives and Contaminants
A G Rico, V Burgat-Sacaze

Abstract

Bound residues may be defined in terms of the nonextractable radioactivity which persists in tissues after administration of radiolabelled compounds to an organism. This fraction is found to contain natural endogenous compounds resulting from incorporation of degradation products of the administered substance into intermediary metabolites (amino acids, carbohydrates etc.). However, 'new' compounds are also found which arise from covalent binding of the administered substance or its metabolites to endogenous macromolecules. The former fraction is nontoxic, but in the second case the nature of the covalent binding is important from the toxicological point of view. It is unspecific and irreversible, and often involves the action of short-lived and highly reactive intermediates. The covalent bond is usually thermodynamically irreversible. A good example is provided by bromobenzene, which binds to proteins via the 3,4-epoxide, which is the hepatotoxic agent. From the above considerations it is possible to distinguish two types of metabolites that may be found in foodstuffs prepared from drug-treated animals. The first are represented by the drug itself and its primary metabolites. These compounds are potentially more or less toxic t...Continue Reading

References

Sep 1, 1977·Journal of Agricultural and Food Chemistry·T C Marshall, H W Dorough
Mar 1, 1977·Journal of Toxicology and Environmental Health·J R Gillette, L R Pohl
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Citations

May 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L A HoogenboomH A Kuiper
May 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I De AngelisA Stammati
Jul 1, 2002·Environmental Toxicology and Pharmacology·Laurentius A P HoogenboomHarry A Kuiper
Jan 1, 1987·Drug Metabolism Reviews·A Y LuG T Miwa
Jan 1, 1990·Drug Metabolism Reviews·A G Rico
Jan 1, 1988·Food Additives and Contaminants·P Evrard, G Maghuin-Rogister
Oct 9, 1998·Food Additives and Contaminants·D M Galer, A M Monro

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