Toxicological study of the butanol fractionated root extract of Asparagus africanus Lam., on some blood parameter and histopathology of liver and kidney in mice

BMC Research Notes
Sintayehu KebedeEyasu Makonnen

Abstract

The butanol fractionated root extract of Asparagus africanus Lam., a traditional herb widely used to treat various ailments were analyzed for the presence of potential toxicity after single (acute) and repeated (subchronic) dose oral administration in adult swiss albino mice using gavages. For the acute study, butanol fractionated extract of the plant was administered in single doses of 1000, 3000 and 5000 mg/kg body weight. In the sub-chronic dose study, the extract was administered at doses of 300 and 600 mg/kg body weight/day for 42 days. Selected hematological and biochemical parameters of the blood followed by histopathological analysis were investigated after 42 days of daily administrations. The results were expressed as M ± SE, and differences at P < 0.05 was considered significant. One way analysis of variance (ANOVA) and least significant difference tests were employed to check the significant differences between the various parameters of the experimental groups. In the acute study, the extract did not caused dose-dependent general behavioral adverse effects, body weight change and mortality. The single dose toxicity studies therefore showed that the butanol fraction of the extract has high safety profile when given o...Continue Reading

References

Aug 1, 1982·Antimicrobial Agents and Chemotherapy·F D GillinM Suffness
Mar 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Jan 1, 1996·Journal of Cardiovascular Pharmacology·S C Body
Nov 14, 1997·Journal of Natural Products·H A Oketch-RabahT Theander
Aug 22, 2007·The Onderstepoort Journal of Veterinary Research·A A AdedapoO G Ohore

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Citations

Nov 8, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Nigatu TuashaZemede Asfaw

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Methods Mentioned

BETA
light microscopy

Software Mentioned

SPSS

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