Toxicological study of various crude extracts of Hyoscyamus gallagheri native to Oman

Toxicology Reports
Doha M AboalolaS Al Touby

Abstract

Cancer is considered a major health issue all over the world for its high morbidity and mortality. Naturally obtained anticancer compounds have comparatively less side-effects, thus it remains a major focus for research. Hyoscyamus gallagheri (H. gallagheri), is one of the plants which have a useful source of bioactive metabolites. The present study is based on preparing plant extracts from the aerial parts of the herbal drug H. gallagheri with various polarities, determining their cytotoxicity and isolating the major cytotoxic compound from the highest active extract. A methanol extract was prepared by the Soxhlet extraction method. Then, it was processed with solvents of increasing polarities. Later, the extracts were evaluated for their cytotoxic activity by brine shrimp lethality assay (BSLA). The highest mass obtained was ethyl acetate and the highest cytotoxicity activity was observed in the ethyl acetate extract, While the lowest was water extract. Ethyl acetate extract was processed for isolation of cytotoxic compounds by different chromatographic methods to give nine fractions which were evaluated by BSLA. Among all, fractions No. 2, 3 and 4 showed significant activity against BSLA and the fractions were purified using...Continue Reading

References

Jan 24, 1997·Biochemical Pharmacology·J M Pezzuto
Feb 23, 2002·Journal of Natural Products·Cui-Ying MaChun-Tao Che
Sep 1, 2005·Bioorganic & Medicinal Chemistry·Vandana SrivastavaSuman P S Khanuja
Jun 12, 2013·Natural Product Research·Wenna ZhangLingyi Kong

❮ Previous
Next ❯

Methods Mentioned

BETA
column chromatography
NMR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved