Toxicology and immunology of Ganoderma lucidum polysaccharides in Kunming mice and Wistar rats

International Journal of Biological Macromolecules
Jianjun ZhangLe Jia

Abstract

In the present work, the toxicology and immunology of polysaccharides from fruiting body of Ganoderma lucidum (GPs) were investigated. No abnormal clinical-symptoms or deaths and no significant difference in body weight and food in-taking rate were found in Wistar rats during the 30-day feeding administration. No significant differences were found in each hematology value, clinical chemistry value and organ/body weight ratio, either. It had no mutagenicity due to the negative experimental results of Ames test, micronucleus test of polychromatic erythrocyte, sperm abnormality test, and chromosome aberration test in Kunming mice, respectively. The immune experiments indicated that high-dose GPs had immune effects in increasing the degree of toe swelling and enhancing the primary immune response to SRBC (P<0.01). But no-significant influence of GPs on the phagocytic function of mononuclear macrophages (MΦ) could be obtained.

References

May 1, 1980·Mutation Research·D R JagannathD J Brusick
Jul 6, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sigrid GlöslIbrahim Elmadfa
Aug 15, 2006·Phytochemistry·R Russell M Paterson
Mar 21, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T SumiyaB Burlinson

❮ Previous
Next ❯

Citations

Jun 29, 2016·Applied Biochemistry and Biotechnology·Zaizhong NiMinggang Li
Aug 17, 2019·Current Vascular Pharmacology·Hoa Thi PhuGianfranco Pintus
Apr 23, 2020·Frontiers in Pharmacology·Abdullah ShaitoGianfranco Pintus
Nov 10, 2018·Frontiers in Pharmacology·Yu CaoJian Gu
Apr 23, 2020·International Journal of Molecular Sciences·Xinling SongLe Jia
Mar 19, 2021·Food Science and Biotechnology·Da-Hong WangJiang-Feng Yuan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Caiqin QinYi Liu
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Yu ZhangYing Zhang
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Jun Zhou, Dingxian Han
© 2022 Meta ULC. All rights reserved