Toxicology of chemically modified graphene-based materials for medical application.

Archives of Toxicology
Toktam NezakatiAlexander M Seifalian

Abstract

This review article aims to provide an overview of chemically modified graphene, and graphene oxide (GO), and their impact on toxicology when present in biological systems. Graphene is one of the most promising nanomaterials due to unique physicochemical properties including enhanced optical, thermal, and electrically conductive behavior in addition to mechanical strength and high surface-to-volume ratio. Graphene-based nanomaterials have received much attention over the last 5 years in the biomedical field ranging from their use as polymeric conduits for nerve regeneration, carriers for targeted drug delivery and in the treatment of cancer via photo-thermal therapy. Both in vitro and in vivo biological studies of graphene-based nanomaterials help understand their relative toxicity and biocompatibility when used for biomedical applications. Several studies investigating important material properties such as surface charge, concentration, shape, size, structural defects, and chemical functional groups relate to their safety profile and influence cyto- and geno-toxicology. In this review, we highlight the most recent studies of graphene-based nanomaterials and outline their unique properties, which determine their interactions un...Continue Reading

References

Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Boyle
Nov 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A H CalvertE Wiltshaw
Feb 13, 1999·Nature·J T SantiniR Langer
Sep 27, 2003·Clinical Therapeutics·Rony Abou-JawdeTarek Mekhail
Oct 2, 2003·Nature Materials·Henning Sirringhaus
Nov 19, 2003·Nature Materials·Amy C Richards GraysonRobert Langer
Nov 19, 2003·Accounts of Chemical Research·Eiichi Nakamura, Hiroyuki Isobe
Dec 4, 2003·European Journal of Medicinal Chemistry·Susanna BosiMaurizio Prato
Oct 23, 2004·Science·K S NovoselovA A Firsov
Dec 9, 2004·Toxicology Letters·Daxiang CuiHuajian Gao
Jun 16, 2005·Bioorganic & Medicinal Chemistry·Stanislav JaraczIwao Ojima
Jul 9, 2005·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
Feb 4, 2006·Science·Andre NelNing Li
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
May 12, 2006·Critical Reviews in Toxicology·Chiu-Wing LamRobert L Hunter
Jul 21, 2006·Nature·Sasha StankovichRodney S Ruoff
Nov 23, 2006·Advanced Drug Delivery Reviews·Lara LacerdaKostas Kostarelos
Mar 3, 2007·Nature Materials·A K Geim, K S Novoselov
Jul 26, 2008·Nature Nanotechnology·Dan LiGordon G Wallace
Jul 30, 2008·Journal of the American Chemical Society·Zhuang LiuHongjie Dai
Apr 25, 2009·Advanced Drug Delivery Reviews·Valerie E Fako, Darin Y Furgeson
May 30, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·B Devika ChithraniDavid A Jaffray
Aug 29, 2009·Nano Letters·Xuesong LiRodney S Ruoff
Sep 10, 2009·Nano Letters·Todd HoareDaniel S Kohane
Sep 29, 2009·Angewandte Chemie·C N R RaoA Govindaraj
Oct 9, 2009·Journal of Photochemistry and Photobiology. B, Biology·Yuan Tang, Anthony J McGoron
Jan 27, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Shuchi AgarwalPeng Chen
Jan 1, 2008·Nano Research·Xiaoming SunHongjie Dai
Apr 9, 2010·Anti-cancer Drugs·Sandra GeigerHans-Joachim Stemmler
May 25, 2010·Advanced Materials·Sungjin ParkRodney S Ruoff

❮ Previous
Next ❯

Citations

Mar 8, 2016·Biomaterials·Evangelia TegouGeorge P Tegos
Jul 22, 2016·Journal of Applied Toxicology : JAT·Eun-Jung ParkDong-Wan Kim
Sep 24, 2016·ACS Applied Materials & Interfaces·Sachin Kumar, Kaushik Chatterjee
Oct 27, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Brian D HoltStefanie A Sydlik
Nov 2, 2016·Particle and Fibre Toxicology·Lingling OuLongquan Shao
Apr 13, 2017·Biomaterials Science·Shine AugustineBansi D Malhotra
Jan 10, 2017·Advanced Drug Delivery Reviews·Uche C Anozie, Paul Dalhaimer
May 8, 2018·Journal of Drug Targeting·Lingyun YiGuangxi Zhai
Dec 8, 2016·Advanced Healthcare Materials·Brian D HoltStefanie A Sydlik
Dec 27, 2018·Photochemistry and Photobiology·Svetlana V MarkovaEugene S Vysotski
Dec 2, 2019·Environmental Science and Pollution Research International·Hanan R H MohamedAkmal A El-Ghor
Feb 18, 2020·Journal of Biomedical Materials Research. Part a·Le HuWei Wu
Feb 2, 2019·Current Medicinal Chemistry·Mário FernandesAndreia C Gomes
Mar 16, 2019·Topics in Current Chemistry·Tabinda Sattar
Jul 31, 2020·Expert Opinion on Drug Delivery·Cuiping JiangQiang Liu
Jul 4, 2018·Chemical Reviews·Toktam NezakatiAlexander M Seifalian

❮ Previous
Next ❯

Methods Mentioned

BETA
biosensing
chemical vapor deposition
transfection
chromosomal aberrations
X-ray
fluorescence imaging

Software Mentioned

SOLiD

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.