Toxicology of Lapachol in rats: embryolethality

Brazilian Journal of Biology = Revista Brasleira De Biologia
Martha de Oliveira GuerraVera Maria Peters

Abstract

Lapachol is a naphtoquinone with therapeutic potential against enterovirus, Chagas disease and is also used as an antimalarial and antiinflamatory agent. In order to study teratogenic potential of Lapachol, pregnant Wistar rats were treated with 0.5 ml of distilled water (control group); 0.5 ml of hydroalcoholic solution (vehicle group) and 10 mg of Lapachol in 0.5 ml of hydroalcoholic solution (treated group) by oral gavage from the 8th to the 12th day of pregnancy. The following variables were observed: maternal body weight on days 1, 6, l5 and 21 and food intake on days 2, 6, 15 and 21 of pregnancy. The number of live and dead fetuses and the sites of resorptions were counted. The ovaries were weighed and the corpora lutea were counted. Data were analyzed by ANOVA-one way, Dunnett test and the chi square test. Significance level test alpha = 0.05. Results have shown that mothers were unaffected but there were a 99.2% of fetus mortality, indicative of a strong abortifacient effect of Lapachol in rats.

References

Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·A V PintoR T Mello
Nov 1, 1975·Journal of Medicinal Chemistry·M da ConsolaçãoM R Sampaio
May 1, 1990·Journal of Ethnopharmacology·E R de AlmeidaC A Lopes
May 1, 1974·The American Journal of Tropical Medicine and Hygiene·F G Austin
Jul 1, 1970·Toxicology and Applied Pharmacology·R K MorrisonD A Cooney

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Citations

Nov 5, 2002·Contraception·André Carvalho FelícioMartha de Oliveira Guerra
Mar 21, 2012·Phytotherapy Research : PTR·Beatrice Nyanchama Kiage-MokuaJürgen Schrezenmeir
Mar 30, 2011·Acta Cirúrgica Brasileira·Roberta Alves HigaAlbert Schiaveto de Souza
Apr 11, 2018·AAPS PharmSciTech·Maria Alice Maciel TabosaLeila Bastos Leal
Apr 11, 2007·Phytotherapy Research : PTR·Rita de Cássia da Silveira E Sá, Martha de Oliveira Guerra

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