Toxicology ontology perspectives

ALTEX
Barry HardyChihae Yang

Abstract

The field of predictive toxicology requires the development of open, public, computable, standardized toxicology vocabularies and ontologies to support the applications required by in silico, in vitro, and in vivo toxicology methods and related analysis and reporting activities. In this article we review ontology developments based on a set of perspectives showing how ontologies are being used in predictive toxicology initiatives and applications. Perspectives on resources and initiatives reviewed include OpenTox, eTOX, Pistoia Alliance, ToxWiz, Virtual Liver, EU-ADR, BEL, ToxML, and Bioclipse. We also review existing ontology developments in neighboring fields that can contribute to establishing an ontological framework for predictive toxicology. A significant set of resources is already available to provide a foundation for an ontological framework for 21st century mechanistic-based toxicology research. Ontologies such as ToxWiz provide a basis for application to toxicology investigations, whereas other ontologies under development in the biological, chemical, and biomedical communities could be incorporated in an extended future framework. OpenTox has provided a semantic web framework for the implementation of such ontologie...Continue Reading

Citations

Jun 26, 2013·Current Opinion in Pharmacology·Alessandra RoncaglioniEmilio Benfenati
Dec 2, 2015·Chemical Research in Toxicology·Donna M DambachDolores Diaz
Feb 22, 2018·Environmental Science. Processes & Impacts·Yu-Mei TanPeter Egeghy
Feb 1, 2018·Bioinformatics·Thomas A DardeFrédéric Chalmel
Jun 14, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin L StephensKatya Tsaioun
Feb 26, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Taylor A M WolffePaul Whaley
Mar 17, 2018·Toxicology and Applied Pharmacology·Ellen V S HesselAldert H Piersma
Feb 29, 2020·Environmental Science & Technology·Jessica D EwaldNiladri Basu
Aug 6, 2014·Journal of Biomedical Semantics·Erfan YounesiManuel C Peitsch

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