Toxicoproteomics -- a new preclinical tool

Drug Discovery Today
Lasantha R Bandara, Sandy Kennedy

Abstract

The publication of the human genome has presented the scientific community with an unprecedented amount of genetic information with the potential to revolutionize the drug discovery process. This information could be used to identify novel drug targets and disease markers or could aid in the development of personalized medicines. The realization that genetic changes must ultimately influence protein function has pushed the field of proteomics further into the limelight. In this review the applications of proteomics to the field of toxicology will be discussed. It is anticipated that, in the future, toxicologists will apply a range of genomic and proteomic techniques to address issues in toxicity.

References

Mar 1, 1997·Electrophoresis·T G MyersJ N Weinstein
Sep 18, 1998·Electrophoresis·N L Anderson, N G Anderson
Sep 18, 1998·Electrophoresis·L AicherS Steiner
Apr 6, 1999·Trends in Biotechnology·W P Blackstock, M P Weir
May 27, 1999·Electrophoresis·F A WitzmannF L Siegel
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M J PageM J O'Hare
Dec 28, 1999·Electrophoresis·P CutlerJ M Skehel
Apr 25, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·W D PennieI Kimber
May 2, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·V B Pai, M C Nahata
Nov 23, 2000·Lancet·U A Meyer
Feb 13, 2001·Current Opinion in Biotechnology·E T FungE A Dalmasso
Mar 17, 2001·Journal of Immunological Methods·D J Cahill
Apr 27, 2001·Toxicology Letters·W D PennieG Orphanides
Apr 28, 2001·Circulation Research·D K ArrellJ E Van Eyk
Jun 8, 2001·Trends in Pharmacological Sciences·M Pirmohamed, B K Park
Aug 11, 2001·Cellular and Molecular Life Sciences : CMLS·A P Jonsson
Sep 1, 2001·Trends in Cardiovascular Medicine·J Macri, S T Rapundalo

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Citations

Feb 24, 2012·Molecules and Cells·Yoen Jung LeeHo Jeong Kwon
Mar 6, 2007·Nihon eiseigaku zasshi. Japanese journal of hygiene·Hidekuni InaderaAkiko Shimomura
Sep 10, 2003·Clinical Pharmacokinetics·Wayne A Colburn, Jean W Lee
Mar 13, 2012·International Journal of Environmental Research and Public Health·Ann Göransson NybergÅke Sellström
Oct 22, 2011·Journal of Proteomics·Li-Rong Yu
Aug 29, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lasantha R BandaraSandy Kennedy
May 6, 2011·Biomaterials·Jasmine J LiLin-Yue Lanry Yung
Jul 23, 2003·Journal of Cellular Biochemistry·Qing-Yu He, Jen-Fu Chiu
Sep 1, 2007·Proteomics. Clinical Applications·José Bermúdez-Crespo, José Luis López
May 25, 2012·Proteomics·Nisha VermaSimone Schmitz-Spanke
Nov 28, 2012·Proteomics. Clinical Applications·Sonja Hess
May 28, 2003·Journal of Chemical Information and Computer Sciences·K KaczmarekB G M Vandeginste
Oct 6, 2007·Expert Opinion on Drug Metabolism & Toxicology·Ben C CollinsStephen R Pennington
Jun 2, 2005·The Journal of Toxicological Sciences·Toshinori YamamotoIkuo Horii
Mar 16, 2006·The Journal of Toxicological Sciences·Rie KikkawaIkuo Horii
Apr 30, 2013·Journal of Proteomics·Nisha VermaSimone Schmitz-Spanke
Feb 9, 2012·Biochimica Et Biophysica Acta·Sohee PharkDonggeun Sul
Jul 15, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Dijendra Nath RoyAyantika Pal
Sep 3, 2011·Journal of Theoretical Biology·Feng ChengJae K Lee
Aug 14, 2012·Environmental Toxicology and Pharmacology·Zai-Yong WangZheng-Tao Wang
Nov 5, 2016·Expert Review of Proteomics·Shankar SumanYogeshwer Shukla
Feb 24, 2010·Toxicology Mechanisms and Methods·Jasmine GeorgeYogeshwer Shukla
Dec 25, 2003·Toxicologic Pathology·Nelson GuerreiroSalah-Dine Chibout
May 18, 2006·Molecular & Cellular Proteomics : MCP·Hélène MeistermannAxel Ducret
Mar 27, 2020·Molecular Genetics & Genomic Medicine·HariOm SinghTapan N Dhole
Dec 13, 2005·Journal of Proteome Research·Milan Randić, Ernesto Estrada
Dec 13, 2005·Journal of Proteome Research·Wen-yu FuYing-nian Yu

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