Toxin-Antitoxin Systems: Implications for Plant Disease

Annual Review of Phytopathology
T Shidore, L R Triplett

Abstract

Toxin-antitoxin (TA) systems are gene modules that are ubiquitous in free-living prokaryotes. Diverse in structure, cellular function, and fitness roles, TA systems are defined by the presence of a toxin gene that suppresses bacterial growth and a toxin-neutralizing antitoxin gene, usually encoded in a single operon. Originally viewed as DNA maintenance modules, TA systems are now thought to function in many roles, including bacterial stress tolerance, virulence, phage defense, and biofilm formation. However, very few studies have investigated the significance of TA systems in the context of plant-microbe interactions. This review discusses the potential impact and application of TA systems in plant-associated bacteria, guided by insights gained from animal-pathogenic model systems.

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Citations

Dec 19, 2019·Frontiers in Plant Science·Camille SyskaAlexandre Boscari
Feb 15, 2021·Applied Microbiology and Biotechnology·Akriti SrivastavaLalit C Garg
Dec 28, 2018·Trends in Biotechnology·Laura M KaminskyTerrence H Bell
Apr 22, 2021·Archives of Microbiology·Malek MarianMasafumi Shimizu
Jun 3, 2021·International Journal of Molecular Sciences·Lidia BossAgnieszka Szalewska-Pałasz
Oct 8, 2021·Frontiers in Microbiology·Isis Gabriela Barbosa CarvalhoAlessandra Alves de Souza

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Methods Mentioned

BETA
chemical treatments
fluorescence microscopy
transgenic

Software Mentioned

TAfinder
RASTA

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