PMID: 6108216Oct 1, 1980Paper

Toxin-induced K+ efflux through the Na+ channel of neuroblastoma cells

European Journal of Biochemistry
Y JacquesM Lazdunski

Abstract

Neurotoxins which modify the gating system of the Na+ channel in neuroblastoma cells and increase the initial rate of 22Na+ influx through this channel also give rise to the efflux of 86Rb+ and 42K+. These effluxes are inhibited by tetrodotoxin and are dependent on the presence in the extracellular medium of cations permeable to the Na+ channel. These stimulated effluxes are not due to membrane depolarization or increases in the intracellular content of Na+ and Ca2+ which occur subsequent to the action of neurotoxins. The relationships of 22Na+ influx and 42K+ (or 86Rb+) effluxes to both the concentration of neurotoxins and the concentration of external permeant cations strongly suggest that the open form of the Na+ channel stabilized by neurotoxins permits an efflux of K+ ions. Our results indicate that for the efflux of each K+ ion there is a corresponding influx of two Na+ ions into the Na+ channel.

References

Sep 21, 1979·Biochimica Et Biophysica Acta·G RomeyM Lazdunski
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D LichtshteinA J Blume
May 1, 1978·The Journal of Physiology·W H Moolenaar, I Spector
Sep 7, 1976·Biochemical and Biophysical Research Communications·C Palfrey, U Z Littauer
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·W A Catterall
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·G Romey Lazdunski
May 5, 1975·Biochemical and Biophysical Research Communications·G RomeyS Lissitzky
Oct 1, 1974·Physiological Reviews·T Narahashi
Jan 1, 1972·International Review of Neurobiology·M H Evans
Nov 28, 1973·Nature: New Biology·I SpectorP G Nelson
Aug 14, 1980·Biochimica Et Biophysica Acta·Y JacquesM Lazdunski
May 1, 1980·European Journal of Biochemistry·Y JacquesM Lazdunski

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Citations

Apr 3, 2002·Drug Development and Industrial Pharmacy·Charles S ChengWeifeng Yu
Jan 1, 1983·Acta Pharmacologica Et Toxicologica·E Heilbronn
Oct 1, 1981·European Journal of Biochemistry·C FrelinM Lazdunski

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