Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation

Eukaryotic Cell
Mathieu GissotKami Kim

Abstract

Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.

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Citations

Apr 7, 2012·Trends in Parasitology·Matthew M CrokenKami Kim
May 18, 2010·Molecular and Biochemical Parasitology·Stacy E DixonWilliam J Sullivan
Jan 12, 2010·Experimental Gerontology·Reid F ThompsonJohn M Greally
May 26, 2009·Ageing Research Reviews·Alexander L Mazin
Dec 27, 2008·Molecular and Biochemical Parasitology·Paul HorrocksRichard D Emes
Aug 2, 2008·Microbes and Infection·Kami Kim, Louis M Weiss
Jan 6, 2009·The Journal of Eukaryotic Microbiology·Mathieu Gissot, Kami Kim
Jan 30, 2010·Cellular Microbiology·Alexandre BougdourMohamed-Ali Hakimi
Dec 18, 2013·Cell Host & Microbe·Nadia PontsKarine G Le Roch
Nov 6, 2008·International Journal for Parasitology·Mathieu GissotJames W Ajioka
Jan 7, 2014·Molecular and Biochemical Parasitology·Kevin T MilitelloErika L Valentine
Jun 23, 2018·Annual Review of Microbiology·Kami Kim
Sep 8, 2016·Antimicrobial Agents and Chemotherapy·Madalyn M McFarlandPaul H Davis
Jan 12, 2019·Chembiochem : a European Journal of Chemical Biology·C A Jabeena, Arumugam Rajavelu
Jan 25, 2014·Nature Reviews. Immunology·Felix Yarovinsky
Oct 31, 2018·Scientific Reports·I Sinha, C J Woodrow
Jan 19, 2019·Scientific Reports·Benoît AliagaChristoph Grunau
Jun 3, 2021·Genes·Mirko Pegoraro, Gareth D Weedall
Aug 31, 2021·Trends in Parasitology·Dayana C Farhat, Mohamed-Ali Hakimi

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