Toxoplasma gondii-derived heat shock protein 70 stimulates the maturation of human monocyte-derived dendritic cells

Biochemical and Biophysical Research Communications
Hyun Kyu KangYoe-Sik Bae

Abstract

We investigated the role of Toxoplasma gondii-derived heat shock protein 70 (TgHSP70) as a dendritic cell (DC) maturation-inducing molecule. TgHSP70 induced the maturation of human monocyte-derived dendritic cells as determined by increased levels of surface markers, namely, CD40, CD80, CD86, and HLA-DR. Moreover, TgHSP70 also reduced phagocytic activity and increased the allostimulatory capacity of DCs, suggesting the functional maturation of DCs by TgHSP70. Maturation of DCs by TgHSP70 also elicited a significant increase in IL-12 production in a polymyxin B-insensitive manner. TgHSP70 also stimulated extracellular signal-regulated kinase and p38 kinase pathways in DCs, and TgHSP70-induced IL-12 production was inhibited by SB203580 but not by PD98059, thus indicating the role of p38 kinase in the maturation of DCs by TgHSP70. This study demonstrates the role of TgHSP70 in the functional maturation of DCs and suggests TgHSP70 as a useful molecule for the development of a vaccine against T. gondii.

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Citations

Jun 2, 2012·Indian Journal of Microbiology·Gautam Kaul, Hitesh Thippeswamy
Sep 14, 2011·Infection and Immunity·Pedro MorgadoMelissa B Lodoen
May 23, 2006·Drug Discovery Today·Brahm H SegalJohn R Subjeck
Jan 23, 2014·Parasitology International·Deyong ChuFumie Aosai
Aug 13, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mitsuhiro IyoriCharles L Sentman
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyun Kyu KangYoe-Sik Bae
May 11, 2017·Frontiers in Cellular and Infection Microbiology·Paulo CzarnewskiNeide M Silva
Apr 30, 2021·Frontiers in Immunology·Rafael Ricci-AzevedoMaria Cristina Roque-Barreira

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