PMID: 11909735Mar 23, 2002Paper

Toxoplasma gondii: in vivo expression of BAG-5 and cyst formation is independent of TNF p55 receptor and inducible nitric oxide synthase functions

Microbes and Infection
Neide M SilvaRicardo T Gazzinelli

Abstract

Wild type, TNFRp55(-/-), iNOS(-/-) and IFN-gamma(-/-) mice were infected with Toxoplasma gondii strain ME-49, and the central nervous system (CNS), lungs, liver, spleen, heart and kidneys were examined for the presence of parasites expressing tachyzoite-specific (SAG-1) and bradyzoite-specific (BAG-5) antigens. During the acute phase of infection, the peripheral organs, but not the CNS, of the IFN-gamma(-/-) mice are heavily parasitized by tachyzoites and there are no signs of parasites expressing BAG-5. In contrast, the tissues from TNFRp55(-/-) and inducible nitric oxide synthase (iNOS)(-/-) mice, mainly the CNS, presented high numbers of parasites expressing SAG-1 and/or BAG-5. Tachyzoite transformation into bradyzoite and cyst development was shown to be normal in the tissues from TNFRp55(-/-) and iNOS(-/-) mice, as indicated by the high numbers of BAG-5/PAS positive cysts. Consistently, reactivation of infection in IFN-gamma(-/-) mice was rapid and characterized by a dramatic increase in SAG-1, contrasting with slow course in the TNFRp55(-/-) or iNOS(-/-) mice associated with a relatively small increase in SAG-1- and/or BAG-5-positive parasites. In conclusion, our results suggest that the control of multiplication of tachy...Continue Reading

References

Jul 1, 1995·Molecular and Biochemical Parasitology·S F ParmleyS Yang
Sep 1, 1996·The Journal of Eukaryotic Microbiology·U GrossD J Ferguson

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Citations

May 10, 2003·Microbes and Infection·Girish M Bhopale
Jun 9, 2009·Experimental Parasitology·Neide Maria SilvaWagner Luiz Tafuri
Apr 25, 2009·Experimental Parasitology·Taísa Carrijo de OliveiraJosé Roberto Mineo
Mar 29, 2008·PLoS Pathogens·Robert W ThompsonThomas A Wynn
Nov 21, 2007·International Journal for Parasitology·Yasuhiro TakashimaKatsuya Kitoh
Apr 20, 2010·International Journal for Parasitology·Heinrich KörnerPhillip Fromm
Oct 17, 2001·Developmental and Comparative Immunology·N F NeumannM Belosevic
Nov 17, 2007·Parasitology International·Yoshifumi NishikawaXuenan Xuan
May 26, 2006·The American Journal of Pathology·Emerson Soares BernardesMaria Cristina Roque-Barreira
Nov 19, 2011·FEMS Microbiology Reviews·William J Sullivan, Victoria Jeffers
Apr 1, 2015·Journal of Microscopy and Ultrastructure·Mohammed A Afifi, Mohammed W Al-Rabia
May 11, 2017·Frontiers in Cellular and Infection Microbiology·Paulo CzarnewskiNeide M Silva
Jun 20, 2017·Parasite : Journal De La Société Française De Parasitologie·Hongchao SunAifang Du

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