PMID: 7026410Aug 1, 1981Paper

Toxoplasma gondii infection of the central nervous system. Use of the peroxidase-antiperoxidase method to demonstrate toxoplasma in formalin fixed, paraffin embedded tissue sections

Human Pathology
F K ConleyJ S Remington

Abstract

The peroxidase-antiperoxidase immunohistochemical technique was employed to stain formalin fixed, paraffin embedded tissue sections from three cases of encephalitis caused by Toxoplasma gondii. We studied two cases of congenital infection and one case of acquired toxoplasmosis occurring in an immunocompromised host. The peroxidase-antiperoxidase method was exquisitely sensitive and highly specific and stained both the encysted and tachyzoite forms of the organism, as well as allowing for easy identification of infected cells. In two cases of necrotizing encephalitis--one congenital, the other acquired--widespread dissemination of the Toxoplasma organism throughout the neural parenchyma was visualized using the peroxidase-antiperoxidase stain. Brain biopsy material that had been obtained eight days prior to death in the case of adult acquired toxoplasmosis did not contain any of the characteristic tissue cysts and was not diagnostic for toxoplasmosis by conventional staining techniques. However, peroxidase-antiperoxidase staining of tissue sections from this biopsy unequivocally demonstrated both free tachyzoites and multiple infected cells. Further application of the peroxidase-antiperoxidase method should increase our understa...Continue Reading

Citations

Dec 1, 1992·Arquivos de neuro-psiquiatria·L R MachadoA Spina-França
Feb 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C S Subauste, J S Remington
Aug 1, 1984·The Journal of Pathology·P R Millard
Aug 19, 1982·The New England Journal of Medicine·W E HauserJ S Remington
Apr 1, 1984·The Journal of Pathology·D I GrahamJ C Siim
Apr 19, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hoil KangYasuhiro Suzuki
Nov 1, 2013·Journal of Wildlife Diseases·Pikka Jokelainen, Turid Vikøren
Jun 2, 1988·The New England Journal of Medicine·A E GlattS H Landesman
Feb 1, 1985·Annals of Tropical Medicine and Parasitology·J HayJ C Siim
May 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C ContiniS Delia
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H KangY Suzuki
May 17, 2001·Antimicrobial Agents and Chemotherapy·N SchölerO Liesenfeld
Jun 17, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xisheng WangYasuhiro Suzuki
Jul 16, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jose G Montoya, Jack S Remington
Jan 1, 1992·Parasitology Research·V LecomteF Santoro
Jan 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·L T Kurland, D W Mulder
Aug 1, 1984·Annals of Tropical Medicine and Parasitology·G N DuttonJ Ralston
Apr 1, 1983·European Journal of Clinical Microbiology·R E McCabe, J S Remington
Jan 1, 1988·Journal of Electron Microscopy Technique·T Sun, S Teichberg
Jul 1, 1993·Revista Do Instituto De Medicina Tropical De São Paulo·R J RochaC A Chiari
Apr 1, 1997·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·W WoudaF van Knapen
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·J HayJ Ralston
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·A DatryM Gentilini
Jul 12, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Llewellyn C Padayachy, A Graham Fieggen
Dec 1, 1984·Zentralblatt für Veterinärmedizin. Reihe A·M M SuterP Oettli
Apr 1, 1990·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·D J Zygmunt
Feb 28, 2002·The Journal of Infectious Diseases·Jose G Montoya

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