Toxoplasma gondii Infection Suppresses House Dust Mite Extract-Induced Atopic Dermatitis in NC/Nga Mice

Allergy, Asthma & Immunology Research
Young Il JeongSang Eun Lee

Abstract

Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that infects humans and animals via congenital or postnatal routes, and it is found worldwide. Modulation of the immune system by parasite infection is proposed to suppress allergic inflammation. Growing evidences have shown that interleukin (IL)-10-producing regulatory B cells (B(regs)) and CD4+CD25+FoxP3+ regulatory T cells (T(regs)) induced by parasite infection play a critical role in allergic or autoimmune diseases because these cells regulate negatively cellular immune responses and inflammation. Currently, the role of IL-10-producing regulatory B cells in host immune response during T. gondii infection is unknown. In this study, we investigate whether T. gondii infection can suppress the development of unrelated atopic dermatitis (AD)-like lesions. AD is a chronically relapsing inflammatory skin disease accompanied by severe itching; for this, we used NC/Nga mice, a well-known experimental model of systemic AD. Repeated exposure to Dermatophagoides farinae crude extract (DfE), known as a major environmental allergen, evokes AD-like skin lesions in NC/Nga mice under specific pathogen-free conditions. NC/Nga mice were intraperitoneally infected w...Continue Reading

References

Oct 26, 2001·Current Opinion in Immunology·J RingH Behrendt
Mar 22, 2002·Nature Reviews. Immunology·M Wills-KarpC L Karp
Sep 24, 2002·Nature Immunology·Simon FillatreauStephen M Anderton
Mar 21, 2003·Journal of Clinical Immunology·Hirokuni HirataTakeshi Fukuda
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niamh E ManganPadraic G Fallon
Mar 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K Matsui, A Nishikawa
Nov 9, 2005·The Journal of Experimental Medicine·Mark S WilsonRick M Maizels
Sep 13, 2006·Parasite Immunology·P ZacconeA Cooke
Jun 5, 2007·Immunobiology·Holger Garn, Harald Renz
Aug 11, 2007·The Journal of Allergy and Clinical Immunology·Hermelijn H SmitsMaria Yazdanbakhsh
Apr 18, 2008·Current Opinion in Immunology·Frances E Lund
Jul 26, 2008·Annals of Neurology·Jorge CorrealeGabriela Razzitte
Nov 27, 2008·Clinical and Experimental Immunology·I FenoyA Goldman
Dec 8, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catherine RonetPascal Launois
Mar 6, 2010·Trends in Parasitology·Stacey A ElmoreJ P Dubey
Mar 23, 2010·The Journal of Allergy and Clinical Immunology·Sylvie AmuPadraic G Fallon
Mar 23, 2010·European Journal of Immunology·Mark S WilsonRick M Maizels
Jun 1, 2010·Immunity·Siamon Gordon, Fernando O Martinez
Apr 5, 2011·Allergy, Asthma & Immunology Research·Myoung Kyu LeeSang-Ha Kim
Jun 21, 2011·The Journal of Allergy and Clinical Immunology·Leonie HussaartsHermelijn H Smits
Jul 9, 2011·Allergy, Asthma & Immunology Research·Geunwoong Noh, Jae Ho Lee
Jan 21, 2012·Journal of Biomedicine & Biotechnology·T P Velavan, Olusola Ojurongbe
Mar 9, 2012·Trends in Immunology·Matthew D TaylorRick M Maizels
May 3, 2013·PLoS Pathogens·Natasha M GirgisP'ng Loke
Feb 11, 2014·Biochemical and Biophysical Research Communications·Young-Il JeongSang-Eun Lee

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Citations

Sep 7, 2018·Parasite Immunology·Candace M de AndradeCamila A Figueiredo
Dec 9, 2017·Immunopharmacology and Immunotoxicology·Michitaka TanakaHirohisa Takano
Jan 31, 2017·International Journal of Molecular Sciences·Xing-Hai JinKyunglim Lee
Nov 19, 2019·Journal of Dermatological Science·Matías Damián Perrone SibiliaAlejandra Goldman
May 18, 2021·Frontiers in Immunology·Diego CatalánOctavio Aravena

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Methods Mentioned

BETA
flow cytometry
ELISA
electrophoresis
light microscopy

Software Mentioned

GraphPad
GraphPad Prism
FlowJo

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