PMID: 9164603May 15, 1997Paper

Toxoplasma gondii: the growth characteristics of three virulent strains

Acta Tropica
P J Appleford, J E Smith

Abstract

We have studied the phenotype of three mouse virulent strains of Toxoplasma gondii (RH, Martin and ENT), monitoring cellular factors which may relate to virulence. There was variation between these three strains in three separate criteria: invasion, growth and tachyzoite-bradyzoite interconversion. The ENT strain exhibited consistently higher invasion rates, a shorter doubling time and a lower frequency of bradyzoite production than Martin or RH strains. In addition to variation in growth rate, there were also differences in the morphology of the parasites, with the ENT strain exhibiting highly synchronous division giving rise to characteristic rosettes. The Martin strain produced bradyzoites at a higher frequency and, in culture, parasites were often seen in tight clusters, which were reminiscent of early tissue cysts. These phenotypic variations amongst mouse-virulent strains of the parasite may imply underlying genetic differences within the group.

Citations

Mar 12, 2009·PloS One·Elizabeth A GaskellGlenn A McConkey
Oct 21, 2011·The Journal of Parasitology·Romain UseoPatrick Gervais
Aug 19, 2003·Journal of Comparative Pathology·S EpiphanioJ L Catão-Dias
Jun 11, 2002·Comparative Immunology, Microbiology and Infectious Diseases·G JungersenP Lind
Oct 12, 2000·International Journal for Parasitology·P J Appleford, J E Smith
Jul 16, 2008·International Journal of Antimicrobial Agents·Kyung-Min ChoiJisoo Yun
Aug 17, 2006·Journal of Evolutionary Biology·K GrechA F Read
Sep 29, 2006·Journal of Medical Microbiology·Songul Bayram DelibasSema Ertug

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