Toxoplasma gondii Vps11, a subunit of HOPS and CORVET tethering complexes, is essential for the biogenesis of secretory organelles

Cellular Microbiology
Juliette Morlon-GuyotWassim Daher

Abstract

Apicomplexan parasites harbour unique secretory organelles (dense granules, rhoptries and micronemes) that play essential functions in host infection. Toxoplasma gondii parasites seem to possess an atypical endosome-like compartment, which contains an assortment of proteins that appear to be involved in vesicular sorting and trafficking towards secretory organelles. Recent studies highlighted the essential roles of many regulators such as Rab5A, Rab5C, sortilin-like receptor and syntaxin-6 in secretory organelle biogenesis. However, little is known about the protein complexes that recruit Rab-GTPases and SNAREs for membrane tethering in Apicomplexa. In mammals and yeast, transport, tethering and fusion of vesicles from early endosomes to lysosomes and the vacuole, respectively, are mediated by CORVET and HOPS complexes, both built on the same Vps-C core that includes Vps11 protein. Here, we show that a T. gondii Vps11 orthologue is essential for the biogenesis or proper subcellular localization of secretory organelle proteins. TgVps11 is a dynamic protein that associates with Golgi endosomal-related compartments, the vacuole and immature apical secretory organelles. Conditional knock-down of TgVps11 disrupts biogenesis of dense...Continue Reading

References

Aug 1, 1991·Molecular and Biochemical Parasitology·A AchbarouJ F Dubremetz
Aug 1, 1988·Parasitology·G CouvreurJ F Dubremetz
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R G Donald, D S Roos
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C SchwabK A Joiner
Dec 16, 1998·Molecular and Biochemical Parasitology·D SoldatiJ C Boothroyd
Apr 10, 1999·Molecular Biology of the Cell·L LecordierM F Cesbron-Delauw
May 18, 1999·The Journal of Biological Chemistry·H HamaB F Horazdovsky
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·D F SealsA Price
May 16, 2002·The Journal of Cell Biology·Keith A Joiner, David S Roos
Jul 23, 2002·Molecular Biology of the Cell·Corinne MercierMarie-France Cesbron-Delauw
Aug 2, 2002·Nature·Laurence PelletierGraham Warren
Jan 28, 2004·Cell·Juan S Bonifacino, Benjamin S Glick
Feb 11, 2005·Eukaryotic Cell·Stacy L PflugerKristin M Hager
May 26, 2005·Biochimica Et Biophysica Acta·Katherine Bowers, Tom H Stevens
Jun 28, 2005·International Journal for Parasitology·Corinne MercierMarie-France-Cesbron Delauw
Nov 29, 2005·Cellular Microbiology·Maryse LebrunJean François Dubremetz
Jul 14, 2006·Current Opinion in Microbiology·Vern Carruthers, John C Boothroyd
Aug 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bianka L GrosshansPeter Novick
Mar 10, 2007·Cellular Microbiology·Jean François Dubremetz
Oct 13, 2007·Autophagy·Clemens W OstrowiczChristian Ungermann
Oct 26, 2007·Molecular and Biochemical Parasitology·Laurence BraunMarie-France Cesbron-Delauw
Nov 13, 2007·Nature Methods·Angelika Herm-GötzMarkus Meissner
Mar 6, 2008·Journal of Cell Science·Henning KesslerMarkus Meissner
Mar 12, 2008·Traffic·Lilach Sheiner, Dominique Soldati-Favre
Apr 16, 2008·Journal of Cell Science·Manami NishiDavid S Roos
Jun 3, 2008·Sub-cellular Biochemistry·Vern B Carruthers, Fiona M Tomley
Nov 5, 2008·The Journal of Cell Biology·Raul RojasJuan S Bonifacino

❮ Previous
Next ❯

Citations

Feb 5, 2016·Molecular and Biochemical Parasitology·Elena Jimenez-RuizMarkus Meissner
Feb 23, 2019·Cellular Microbiology·David J Dubois, Dominique Soldati-Favre
Nov 16, 2019·Parasitology·Alana BurrellVirginia Marugan-Hernandez
Jul 19, 2020·Annual Review of Microbiology·Yifan WangJeroen P J Saeij
Feb 6, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuang LiQun Liu
Jan 29, 2021·Life·Olivia L McGovernVern B Carruthers
Dec 29, 2020·Molecular Microbiology·Rouaa Ben ChaabeneDominique Soldati-Favre
May 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Srinivasan RamakrishnanRoberto Docampo
May 29, 2021·Trends in Parasitology·Daniela Sparvoli, Maryse Lebrun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.