Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface.

Annual Review of Microbiology
Yifan WangJeroen Pj Saeij

Abstract

Many intracellular pathogens, including the protozoan parasite Toxoplasma gondii, live inside a vacuole that resides in the host cytosol. Vacuolar residence provides these pathogens with a defined niche for replication and protection from detection by host cytosolic pattern recognition receptors. However, the limiting membrane of the vacuole, which constitutes the host-pathogen interface, is also a barrier for pathogen effectors to reach the host cytosol and for the acquisition of host-derived nutrients. This review provides an update on the specialized secretion and trafficking systems used by Toxoplasma to overcome the barrier of the parasitophorous vacuole membrane and thereby allow the delivery of proteins into the host cell and the acquisition of host-derived nutrients.

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Citations

Oct 30, 2020·Molecular Microbiology·Leonardo AugustoWilliam J Sullivan
Apr 28, 2021·Parasitology International·Fumiaki Ihara, Yoshifumi Nishikawa
May 28, 2021·Cell Host & Microbe·Alex Rosenberg, L David Sibley

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