Toxoplasmosis in immunoglobulin M-suppressed mice.

Infection and Immunity
J K Frenkel, D W Taylor

Abstract

Mice challenged with a pathogenic strain of Toxoplasma gondii develop fatal infections. However, if such mice are initially treated with sulfadiazine (SD), they develop immunity and survive with chronic infections. The role of antibody (Ab) in establishing protective immunity against acute parasitemias and in maintaining chronic infections was investigated using B-cell-deficient (immunoglobulin M-suppressed), T-cell-deficient (athymic), and normal BALB/c mice. All mice not receiving SD treatment rapidly died (mean 7.5 days) after infection, but the majority (80%) of intact mice developed immunity during SD treatment and survived for over 5 months with chronic toxoplasmosis. Athymic mice rapidly died (mean 6.0 days) after the removal of SD treatment. Although all SD-treated immunoglobulin M-suppressed mice eventually died, they lived considerably longer (18 to 83 days) in the complete absence of antitoxoplasma Ab than unprotected mice (7 to 9 days). Histopathological sections of liver, lung, brain, and other tissues showed that toxoplasma organisms gave rise to fatal lesions in all nonsurviving animals. The injection of Ab into acutely infected and athymic mice imparted no protection, but transfer of antitoxoplasma Ab (titer gre...Continue Reading

References

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Citations

Feb 26, 2000·Infection and Immunity·P C SaylesL L Johnson
Aug 2, 2012·Infection and Immunity·Arielle Glatman ZaretskyChristopher A Hunter
Dec 19, 2001·Infection and Immunity·Lawrence L Johnson, Peter C Sayles
Feb 28, 2002·The Journal of Infectious Diseases·Yasuhiro Suzuki
May 5, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xisheng WangYasuhiro Suzuki
Jan 1, 1992·FEMS Microbiology Immunology·C S PaviaK E Curnick
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason P GigleyDavid J Bzik
Nov 14, 2006·Parasite Immunology·L A JonesC W Roberts
Mar 1, 1996·Infection and Immunity·C W RobertsJ Alexander
Apr 1, 1987·Infection and Immunity·L Reyes, J K Frenkel
Jan 1, 1986·The Journal of Pediatrics·C B Wilson

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