Abstract
Mice challenged with a pathogenic strain of Toxoplasma gondii develop fatal infections. However, if such mice are initially treated with sulfadiazine (SD), they develop immunity and survive with chronic infections. The role of antibody (Ab) in establishing protective immunity against acute parasitemias and in maintaining chronic infections was investigated using B-cell-deficient (immunoglobulin M-suppressed), T-cell-deficient (athymic), and normal BALB/c mice. All mice not receiving SD treatment rapidly died (mean 7.5 days) after infection, but the majority (80%) of intact mice developed immunity during SD treatment and survived for over 5 months with chronic toxoplasmosis. Athymic mice rapidly died (mean 6.0 days) after the removal of SD treatment. Although all SD-treated immunoglobulin M-suppressed mice eventually died, they lived considerably longer (18 to 83 days) in the complete absence of antitoxoplasma Ab than unprotected mice (7 to 9 days). Histopathological sections of liver, lung, brain, and other tissues showed that toxoplasma organisms gave rise to fatal lesions in all nonsurviving animals. The injection of Ab into acutely infected and athymic mice imparted no protection, but transfer of antitoxoplasma Ab (titer gre...Continue Reading
References
Mar 1, 1975·The Journal of Infectious Diseases·J K Frenkel, S A Caldwell
Aug 25, 1977·Zeitschrift Für Parasitenkunde·T ShirahataN Suzuki
Mar 1, 1978·Cellular Immunology·E D JohnsonH C Morse
Sep 27, 1979·Nature·Y J Rosenberg, C B Evans
Sep 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·G A Ahronheim
Mar 1, 1978·Infection and Immunity·M Chinchilla, J K Frenkel
Jan 1, 1975·Human Pathology·J K FrenkelJ Arias-Stella
Jun 1, 1973·Immunochemistry·W C EbyR G Mage
Aug 23, 1968·Science·J S Remington, T C Merigan
Feb 1, 1972·The Journal of Experimental Medicine·A R LawtonM D Cooper
Feb 1, 1981·Infection and Immunity·A M RodriguezA Capron
Dec 10, 1948·Science·A B Sabin, H A Feldman
Citations
May 13, 1999·Parasite Immunology·L ZennerM F Cesbron-Delauw
Apr 23, 2014·Infection and Immunity·Qila SaYasuhiro Suzuki
Feb 26, 2000·Infection and Immunity·P C SaylesL L Johnson
Aug 2, 2012·Infection and Immunity·Arielle Glatman ZaretskyChristopher A Hunter
May 1, 1991·Clinical and Experimental Immunology·S J ParkerJ Alexander
Jan 18, 2002·Infection and Immunity·Lori CasciottiImtiaz A Khan
Dec 19, 2001·Infection and Immunity·Lawrence L Johnson, Peter C Sayles
Feb 28, 2002·The Journal of Infectious Diseases·Yasuhiro Suzuki
May 5, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xisheng WangYasuhiro Suzuki
Jan 1, 1992·FEMS Microbiology Immunology·C S PaviaK E Curnick
Dec 26, 2003·Microbiology and Immunology·Mei ChenAkihiko Yano
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason P GigleyDavid J Bzik
May 21, 2016·Frontiers in Microbiology·Xiao T ChingYee L Lau
Nov 14, 2006·Parasite Immunology·L A JonesC W Roberts
Feb 6, 2020·Frontiers in Immunology·Patricia M SikorskiMichael E Grigg
Jul 19, 2017·The American Journal of Tropical Medicine and Hygiene·Xiao Teng ChingYee Ling Lau
May 1, 2021·Vaccines·Hae-Ji KangFu-Shi Quan
May 1, 1985·Infection and Immunity·M SiqueiraG Biozzi
Mar 1, 1996·Infection and Immunity·C W RobertsJ Alexander
Apr 1, 1987·Infection and Immunity·L Reyes, J K Frenkel
Apr 1, 1987·Infection and Immunity·V BrinkmannS D Sharma
Jan 1, 1986·The Journal of Pediatrics·C B Wilson