PMID: 9423889Jan 10, 1998Paper

ToxR-independent expression of cholera toxin from the replicative form of CTXphi

Infection and Immunity
S Lazar, M K Waldor

Abstract

The ctxAB operon, which encodes cholera toxin, resides in the genome of CTXphi, a filamentous bacteriophage. Within Vibrio cholerae cells, the CTXphi genome can exist either as a replicating plasmid or as a prophage integrated into the chromosome. Previous work established that ToxR is required for chromosomal ctxAB expression. We have learned that strains harboring the CTXphi replicative form produce cholera toxin under all conditions tested, independently of ToxR. During passage of CTXphi lysogens through the infant mouse intestine, transduction of CTXphi to a recipient strain can be detected, indicating that phage excision and replication occur in vivo. These results suggest that phage induction might provide a novel mechanism for the regulation of cholera toxin production.

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Citations

Jul 16, 2002·Infection and Immunity·Patrick L Wagner, Matthew K Waldor
Jul 19, 2002·Proceedings. Biological Sciences·J Smith
Oct 26, 1999·Infection and Immunity·S M FaruqueJ J Mekalanos
Jul 19, 2000·Infection and Immunity·S M FaruqueD A Sack
Jun 28, 2005·Molecular Microbiology·Sarah M McLeodMatthew K Waldor
Jun 15, 2018·Science Translational Medicine·Troy P HubbardMatthew K Waldor
Nov 30, 2011·Future Microbiology·Veronica Casas, Stanley Maloy
Dec 4, 2003·Molecular Microbiology·Gillian D PullingerAlistair J Lax
Dec 9, 2004·DNA and Cell Biology·Shah M FaruqueJohn J Mekalanos
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·S M FaruqueJ J Mekalanos
Aug 26, 1998·Infection and Immunity·H H Kimsey, M K Waldor
Aug 26, 1998·Infection and Immunity·D W AchesonM K Waldor
Jan 24, 2004·Lancet·David A SackA K Siddique

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