PMID: 7546836Jan 1, 1995Paper

TP53 abnormalities and genetic instability in breast cancer

Acta Oncologica
J E EyfjördK Anamthawat-Jonsson

Abstract

TP53 abnormalities in breast carcinomas and inherited TP53 changes in breast cancer patients and in Li-Fraumeni-like families were looked for. Tumours were screened for mutations in the TP53 gene by means of the PCR-CDGE method followed by PCR and direct sequencing. Allelic loss was determined by polymorphic markers, by comparing normal and tumour DNA. Abnormal protein expression was examined by immunohistochemical staining. TP53 abnormalities in the tumours were examined in relation to genetic instability, clinical data and family history. Genetic instability was studied by detection of oncogene amplification, allelic loss, karyotype analysis and fluorescent in situ hybridization, FISH. Our studies showed that TP53 abnormalities were significantly associated with amplification of the erbB2 oncogene and allelic loss on chromosome 17. Chromosomal abnormalities were also significantly more common in tumours with TP53 abnormalities. Looking at clinical data we found significant association between TP53 abnormalities and poor prognosis.

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Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·Y MiyoshiS Noguchi
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·R KissI Salmon
Jul 24, 1998·Mutation Research·K R TindallT A Kunkel
Mar 5, 1999·Breast Cancer Research and Treatment·R Dahiya, G Deng
Aug 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Adam ShlienDavid Malkin
Nov 7, 1999·Journal of Cutaneous Pathology·A J MarrogiE McBurney
Oct 1, 2011·Breast Cancer Research : BCR·Olafur A StefanssonJorunn E Eyfjord
Jun 5, 2002·Nature Reviews. Cancer·Tomasz Skorski
Nov 7, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P GargalloA Cañete
Nov 21, 2019·International Journal of Molecular Sciences·Graeme Benstead-HumeFrances M G Pearl
Apr 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·J H LichyJ K Taubenberger

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