TP53-Deficient Angiosarcoma Expression Profiling in Rat Model

Cancers
Urszula SmyczyńskaPaweł Grieb

Abstract

Sarcomas are a heterogeneous group of malignant tumors, that develop from mesenchymal cells. Sarcomas are tumors associated with poor prognosis and expected short overall survival. Efforts to improve treatment efficacy and treatment outcomes of advanced and metastatic sarcoma patients have not led to significant improvements in the last decades. In the Tp53C273X/C273X rat model we therefore aimed to characterize specific gene expression pattern of angiosarcomas with a loss of TP53 function. The presence of metabolically active tumors in several locations including the brain, head and neck, extremities and abdomen was confirmed by magnetic resonance imaging (MRI) and positron emission tomography (PET) examinations. Limb angiosarcoma tumors were selected for microarray expression analysis. The most upregulated pathways in angiosarcoma vs all other tissues were related to cell cycle with mitosis and meiosis, chromosome, nucleosome and telomere maintenance as well as DNA replication and recombination. The downregulated genes were responsible for metabolism, including respiratory chain electron transport, tricarboxylic acid (TCA) cycle, fatty acid metabolism and amino-acid catabolism. Our findings demonstrated that the type of devel...Continue Reading

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Citations

Aug 6, 2020·Cancers·Anna M CzarneckaPiotr Rutkowski
Jun 3, 2021·Cancers·Youri I Pavlov

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Methods Mentioned

BETA
ubiquitination
GTPase
PCR
genotyping
gene knockouts

Software Mentioned

Ingenuity Pathway Analysis ( IPA
AffySTExpressionFileCreator
Gene Set Enrichment Analysis ( GSEA )
Cytoscape
GSEA
GenePattern
CMap
PMOD

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