TP53 dysfunction in diffuse large B-cell lymphoma

Critical Reviews in Oncology/hematology
Ting-Xun LuJian-Yong Li

Abstract

The aberrations of TP53 gene and dysregulation of the TP53 pathway are important in the pathogenesis of many human cancers, including malignant lymphomas, especially for diffuse large B cell lymphoma (DLBCL). By regulating many downstream target genes or molecules, TP53 governs major defenses against tumor growth and promotes cellular DNA repair, apoptosis, autophagy, cell cycle arrest, signaling, transcription, immune or inflammatory responses and metabolism. Dysfunction of TP53, including microRNA regulations, copy number alterations of TP53 pathway and TP53 itself, dysregulation of TP53 regulators, and somatic mutations by abnormal TP53 function modes, play an important role in lymphoma generation, progression and invasion. The role of TP53 in DLBCL has been widely explored recently. In this review, we summarized recent advances on different mechanisms of TP53 in DLBCL and new therapeutic approaches to overcome TP53 inactivation.

References

Jul 2, 1992·Nature·D P Lane
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K LeroyUNKNOWN Groupe d'Etude des Lymphomes de l'Adulte
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Feb 4, 2006·Molecular Cell·Christopher L Brooks, Wei Gu
Mar 25, 2006·Cell Death and Differentiation·A J LevineZ Feng
May 24, 2006·The Journal of Cell Biology·Chad D KnightsMaria Laura Avantaggiati
May 27, 2006·Science·Ken Garber
Jul 6, 2006·Medical Molecular Morphology·Manabu MatsumotoYuji Ohtsuki
Nov 28, 2006·Nature Reviews. Cancer·Franck Toledo, Geoffrey M Wahl
Jan 20, 2007·The Journal of Clinical Investigation·Ravi K AmaravadiCraig B Thompson
Jul 17, 2007·Cell Cycle·Natasha D Marchenko, Ute M Moll
Nov 15, 2007·Nature Reviews. Molecular Cell Biology·Ruth Geiss-Friedlander, Frauke Melchior
Dec 22, 2007·Nature Reviews. Immunology·Ulf Klein, Riccardo Dalla-Favera
May 20, 2008·Cell·Yi TangWei Gu
Aug 23, 2008·Cell Cycle·Stephanie Carter, Karen H Vousden
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Georg LenzLouis M Staudt
Sep 4, 2008·Cellular and Molecular Life Sciences : CMLS·S J YeungM-H Lee
Jan 24, 2009·Nature Reviews. Cancer·Catherine WhibleyMonica Hollstein
Mar 19, 2009·Genes & Development·Minh T N LeBing Lim
May 5, 2009·Cell·Karen H Vousden, Carol Prives
Sep 25, 2009·Nature Reviews. Cancer·Shirley Polager, Doron Ginsberg
Sep 25, 2009·Nature Reviews. Cancer·Arnold J Levine, Moshe Oren
Nov 26, 2009·Critical Reviews in Biochemistry and Molecular Biology·Karen A Boehme, Christine Blattner
Feb 2, 2010·The Journal of Biological Chemistry·Jing HuangShelley L Berger
Apr 16, 2010·The New England Journal of Medicine·Georg Lenz, Louis M Staudt
Jun 15, 2010·Molecular Cell·Wenwei HuZhaohui Feng
Oct 12, 2010·Trends in Molecular Medicine·Chao Dai, Wei Gu
Jan 5, 2011·Cell Cycle·Alexander H Stegh, Ronald A DePinho
Jan 6, 2011·JAMA : the Journal of the American Medical Association·Muller FabbriCarlo M Croce
Aug 30, 2011·International Journal of Oncology·Lenka StefancikovaJana Smardova
Sep 24, 2011·Cell Death and Differentiation·V MarcelJ-C Bourdon

❮ Previous
Next ❯

Citations

Dec 17, 2017·Journal of Experimental & Clinical Cancer Research : CR·Haige YeMichael L Wang
Feb 22, 2018·Journal of Clinical Neuromuscular Disease·Ahmad DaherKarin Woodman
Jun 9, 2016·Advances in Anatomic Pathology·Penelope KorkolopoulouMaria Ioannou
Dec 4, 2016·Hematology·Bertrand Coiffier, Clémentine Sarkozy
Jul 25, 2019·Frontiers in Oncology·Amy Guimaraes-YoungAdam J Dupuy
Jul 20, 2016·Oncology Reports·Ming WanYun-Fu Cui
Mar 16, 2017·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Luciana Guedes de AlmeidaAdenilson de Souza da Fonseca
Jan 29, 2021·Current Hematologic Malignancy Reports·Edward NabrinskyPaul B Koller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Iranian Journal of Immunology : IJI
Mohammadreza AtaollahiBehnoosh Miladpoor
Genetics and Molecular Biology
Diego d'Avila PaskulinPatricia Ashton-Prolla
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Saskia A G M CillessenJoost J Oudejans
© 2021 Meta ULC. All rights reserved