TP53 genotype but not p53 immunohistochemical result predicts response to preoperative short-term radiotherapy in rectal cancer

Annals of Surgery
Daniela KandiolerFriedrich Herbst

Abstract

To evaluate and compare the predictive power of p53 gene analysis versus p53 immunohistochemical staining in terms of response to preoperative short-term radiotherapy using 25 Gy in operable rectal cancer. Recent studies show that p53 may be a determinant of radiosensitivity being required for induction of apoptosis in case of radiation-induced DNA damage. Preirradiation biopsy samples of 64 patients with rectal carcinoma were analyzed. Genetic alterations of the p53 gene were detected by complete direct sequencing of exons 2 to 10. Expression of the nuclear phosphoprotein p53 was assessed by immunohistochemical staining. Results were correlated with histopathology of resected specimens and follow-up data, respectively. Mutations of the p53 gene were present in 45% of tumors. Patients with a normal p53 gene had a significant survival advantage. Comparing pre- and postradiotherapy T category, a reduction was seen in patients with normal p53 genotype only. A mutant p53 genotype was highly specific in indicating stable disease concerning T category after irradiation. Protein overexpression was detected in 61%. Overexpression of the p53 protein was not related to survival or response. The concordance between immunohistochemistry an...Continue Reading

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References

Sep 1, 1995·Nature Medicine·J Milner
Nov 4, 1994·Science·S W LoweT Jacks
Apr 3, 1997·The New England Journal of Medicine·UNKNOWN Swedish Rectal Cancer TrialN Wilking
Nov 15, 1997·The British Journal of Surgery·N R Ahmad, D Nagle
Jan 1, 1997·British Medical Bulletin·C O Bellamy
Mar 11, 1998·Breast Cancer Research and Treatment·A DegeorgesM Marty
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·A TannapfelC Wittekind
Mar 17, 1999·International Journal of Radiation Oncology, Biology, Physics·R J MyersonB Walz
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·U KressnerG Lindmark
May 11, 1999·Annals of Surgery·J N VautheyE M Copeland
Aug 6, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G AdellB Nordenskjöld

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Citations

Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·John R PetersenDeborah A Payne
Oct 5, 2002·Cancer Treatment Reviews·Bruce D Minsky
Nov 20, 2002·ANZ Journal of Surgery·Bruce Minsky
Aug 1, 2007·Clinics in Colon and Rectal Surgery·Smitha S KrishnamurthiTimothy J Kinsella
Jul 7, 2005·Journal of the National Cancer Institute·William L InceHartmut Koeppen
Mar 18, 2005·Acta chirurgica Iugoslavica·M MicevI Popov
Dec 17, 2008·Acta chirurgica Iugoslavica·V ValentiniM C Barba
Aug 10, 2004·International Journal of Cancer. Journal International Du Cancer·Eva FernebroMef Nilbert
Nov 5, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Jennifer E RyanAlexander G Heriot
Jun 7, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vincenzo ValentiniChristine Verfaillie
Sep 17, 2010·The British Journal of Surgery·F M SmithD C Winter
Dec 6, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F M SmithM J Kennedy
Oct 11, 2005·International Journal of Radiation Oncology, Biology, Physics·Fraser M SmithM John Kennedy
Mar 17, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N PilatD Kandioler
Sep 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio RussoUNKNOWN TP53-CRC Collaborative Study Group
Sep 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick G Johnston
May 16, 2006·Arquivos De Gastroenterologia·Márcia Teresinha JurachLuis Fernando Moreira
Apr 28, 2005·British Journal of Cancer·F M SmithJ V Reynolds
Jul 8, 2009·Expert Review of Molecular Diagnostics·Sergio HuertaDebabrata Saha
Mar 14, 2018·Cancer Medicine·Meng LiuJohn L Villano
Aug 17, 2018·Annals of the New York Academy of Sciences·Tamara BraunschmidDaniela Kandioler
May 6, 2019·Virchows Archiv : an International Journal of Pathology·Dan JiangKun Li
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Per Eystein Lønning, Anne-Lise Børresen-Dale
Nov 11, 2019·Cancer Research·Sylvain FerrandonMatthew F Kalady
Aug 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Inti ZlobecCarolyn C Compton
Sep 16, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Gonçalves-RibeiroD G Molleví
Jul 7, 2007·The Lancet Oncology·Brian D P O'NeillDiana M Tait

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