TP53 mutation profile of esophageal squamous cell carcinomas of patients from Southeastern Brazil

Mutation Research
Ana RossiniLuis Felipe Ribeiro Pinto

Abstract

Esophageal cancer (EC) is among the 10 most common and fatal malignacies in the world, presenting a marked geographic variation in incidence rates between and within different countries. The TP53 tumor suppressor gene is highly mutated in esophageal tumors and its mutation pattern can offer clues to the etiopathology of the tumor. As Brazil presents one of the highest incidence areas in the West, a deeper knowledge of the molecular mechanisms related to EC development in the Brazilian population is needed. We analyzed the mutation profile of 110 esophageal squamous cell carcinomas (ESCC) of patients from Southeastern Brazil (Rio de Janeiro and São Paulo) and collected data regarding alcohol intake and tobacco smoking. We detected 41 mutations in tumor samples from 38 patients. There was no association between mutation frequency and tobacco smoking or alcohol drinking. The most frequently mutated codons were 179, 214, 220 and 248. Codons 179, 220 and 248 are hot-spots for ESCC, but codon 214 presents only 0.7% of the mutations registered in the IARC database. The mutation profile revealed a high percentage of mutations at A:T base pairs (34.1%) followed by deletions (17.1%). We concluded that the mutation profile detected in thi...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Apr 1, 1994·International Journal of Cancer. Journal International Du Cancer·J HuX Xu
Jun 21, 1996·International Journal of Cancer. Journal International Du Cancer·R MontesanoP Hainaut
Jul 27, 1999·International Journal of Cancer. Journal International Du Cancer·X CastellsaguéM J Quintana
Nov 5, 1999·Advances in Cancer Research·P Hainaut, M Hollstein
Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·X CastellsaguéP A Rolón
Oct 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M ParkinS S Devesa
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Arno PützHartmut M Rabes
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·A Paloma VizcainoD Maxwell Parkin
Oct 23, 2002·Critical Reviews in Toxicology·Janne HukkanenHannu Raunio
Mar 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Timothy E BaroniRainer K Brachmann
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
May 8, 2007·Trends in Cell Biology·Karim Bensaad, Karen H Vousden
Dec 12, 2007·Best Practice & Research. Clinical Gastroenterology·R Lambert, P Hainaut
Sep 20, 2008·Cancer Gene Therapy·M OlivierP Hainaut
Sep 25, 2008·Biochemical Pharmacology·Ella KimWolfgang Deppert
Nov 22, 2008·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Takafumi Nishimura
Mar 17, 2009·Current Opinion in Structural Biology·Andrei L Okorokov, Elena V Orlova
May 6, 2009·International Journal of Cancer. Journal International Du Cancer·Farhad IslamiFarin Kamangar

❮ Previous
Next ❯

Citations

Jul 11, 2013·Bioscience Reports·Nathalia Meireles da CostaLuis Felipe Ribeiro Pinto
Mar 5, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·X C WuJ R Zhang
Mar 8, 2018·The Journal of Pharmacy and Pharmacology·Nathalia Regina F LealMarsen Garcia Pinto Coelho
Apr 5, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·C F LacerdaR M Reis
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Carlos F Araujo-LimaIsrael Felzenszwalb
Sep 16, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MurphyP Brennan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.