TP53 mutations predict for poor survival in ALK rearrangement lung adenocarcinoma patients treated with crizotinib

Journal of Thoracic Disease
Wen-Xian WangYong Song

Abstract

Advanced non-small cell lung cancer (NSCLC) patients who harbor anaplastic lymphoma kinase (ALK) rearrangement are sensitive to an ALK inhibitor (crizotinib), but not all ALK-positive patients benefit equally from crizotinib treatment. We analyze the impact of TP53 mutations on response to crizotinib in patients with ALK rearrangement NSCLC. Sixty-six ALK rearrangement NSCLC patients receiving crizotinib were analyzed. 21 cases were detected successfully by the next generation sequencing validation FFPE before crizotinib. TP53 mutations were evaluated in 8 patients in relation to disease control rate (DCR), objective response rate (ORR), progression-free survival (PFS) and overall survival (OS). TP53 mutations were observed in 2 (25.00%), 1 (12.50%), 1 (12.50%) and 4 (50.00%) patients in exons 5, 6, 7 and 8, respectively. The majority of patients were male (75.00%, 6/8), less than 65 years old (62.50%, 5/8) and never smokers (75.00%, 6/8). ORR and DCR for crizotinib in the entire case series were 61.90% and 71.43%, respectively. Statistically significant difference was observed in terms of PFS and OS between TP53 gene wild group and mutation group patients (P=0.038, P=0.021, respectively). TP53 mutations reduce responsiveness t...Continue Reading

Citations

Nov 7, 2019·Journal of Cancer Research and Clinical Oncology·Yuan TangDongmei Lin
Sep 29, 2019·Cancer Biology & Therapy·Na LiuYu Yao
Jun 28, 2019·Molecular Cancer Therapeutics·Mathilde Couëtoux du TertreJason Agulnik
Jun 28, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shannon S ZhangSai-Hong Ignatius Ou
Jul 27, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rafal DziadziuszkoShirish M Gadgeel
Sep 20, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·D Ross CamidgeSanjay Popat
Jan 20, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mei-Mei ZhengYi-Long Wu
Sep 24, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Che-Jui LeeAgnieszka Wozniak

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