Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals

Molecular Psychiatry
Christina G BaehneA J Fallgatter

Abstract

Although therapeutic interventions in attention-deficit/hyperactivity disorder (ADHD) still focus on the dopaminergic system, recent studies indicate a serotonergic dysfunction in this disease as well. In that respect, several variants of the tryptophan hydroxylase gene (TPH2), which codes for the rate-limiting enzyme in the biosynthesis of serotonin (5-HT), have been associated with ADHD. The rs4570625 G-allele polymorphisms of the TPH2 gene have already been related to altered reactivity of the brain during perception tasks with emotional stimuli in healthy adults. Here we investigated the influence of the ADHD related risk alleles for rs4570625 and for rs11178997 on prefrontal brain function during cognitive response control in large samples of adult ADHD patients (n=124) and healthy controls (n=84). Response control was elicited with a Go-NoGo task (continuous performance test; CPT) performed during recording of an ongoing EEG. From the resulting event-related potentials in the Go- and NoGo conditions of the CPT, the NoGo-anteriorization (NGA) has been calculated as a valid neurophysiological parameter for prefrontal brain function. In the current study, ADHD risk alleles of both polymorphisms were found to be associated wi...Continue Reading

References

Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·G GrattonE Donchin
Oct 1, 1994·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·R D Pascual-MarquiD Lehmann
Aug 26, 1998·Electroencephalography and Clinical Neurophysiology·W K StrikR D Pascual-Marqui
Apr 3, 2001·The International Journal of Neuropsychopharmacology·Andreas J. FallgatterK. Peter Lesch
Mar 29, 2002·American Journal of Medical Genetics·James M BjorkCraig L Hanis
Jul 12, 2002·Journal of Neural Transmission·A J FallgatterM J Herrmann
Nov 29, 2002·Psychopharmacology·Espen WalderhaugAndres Magnusson
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Apr 16, 2003·Psychiatry Research·Stefan KaiserMatthias Weisbrod
Apr 17, 2003·British Medical Bulletin·Ahmad R Hariri, Daniel R Weinberger
Oct 18, 2003·Biochemical Pharmacology·Diego J Walther, Michael Bader
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Francine CôtéGuilan Vodjdani
Mar 9, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andreas J FallgatterAndreas Warnke
Jun 10, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andreas J FallgatterKlaus-Peter Lesch
Nov 6, 2004·Neuroscience and Biobehavioral Reviews·P HeiserJ Hebebrand
Jun 9, 2005·Molecular Psychiatry·K SheehanZ Hawi
Oct 26, 2005·Journal of Neural Transmission·T CanliK P Lesch
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andreas J FallgatterJürgen Deckert
Dec 21, 2006·The International Journal of Neuropsychopharmacology·Lise GutknechtKlaus-Peter Lesch

❮ Previous
Next ❯

Citations

Jun 17, 2008·Der Nervenarzt·T J RennerK-P Lesch
Jul 31, 2008·Journal of Neural Transmission·Lise GutknechtKlaus-Peter Lesch
Feb 11, 2010·European Child & Adolescent Psychiatry·Tobias BanaschewskiDavid Coghill
Mar 24, 2011·Expert Reviews in Molecular Medicine·Charlotte TyePhilip Asherson
Aug 31, 2011·Molecular Psychiatry·T D R CumminsM A Bellgrove
Nov 23, 2011·Molecular Psychiatry·B FrankeUNKNOWN International Multicentre persistent ADHD CollaboraTion
Jul 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas DreslerAndreas J Fallgatter
Oct 24, 2012·Cognitive Neuropsychiatry·Tamsyn E Van Rheenen, Susan L Rossell
May 24, 2012·Cerebral Cortex·Sebastian HeinzelAnn-Christine Ehlis
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Klaus-Peter LeschLise Gutknecht
Dec 3, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kelli LehtoJaanus Harro
Apr 2, 2014·Molecular Neurobiology·Zhaomin WuYufeng Wang
Oct 14, 2011·Journal of Applied Genetics·Konstantin A PavlovVladimir P Chekhonin
Jun 5, 2012·Journal of Psychiatric Research·Anna SchuhmacherRainald Mössner
Jun 23, 2012·Journal of Psychiatric Research·Peter A FaschingElisabeth B Binder
Jan 25, 2011·Psychoneuroendocrinology·Jonas WaiderKlaus-Peter Lesch
Dec 17, 2008·Behavioural Brain Research·Roman OsinskyJuergen Hennig
Jul 14, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Mirko DoehnertHans-Christoph Steinhausen
Apr 14, 2016·Genetics Research International·Karina VillalbaJean Lud Cadet
Mar 15, 2011·Biological Psychiatry·Jessica J M BarnesMark A Bellgrove
Jul 28, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Johannes ThomeManfred Gerlach
Dec 19, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andreas J FallgatterKlaus-Peter Lesch
Mar 9, 2010·NeuroImage·Sarah Durston
Feb 17, 2015·Neurochemistry International·Emili Banerjee, Krishnadas Nandagopal
Jun 27, 2014·Frontiers in Human Neuroscience·Laura S van VelzenOdile A van den Heuvel
May 21, 2016·Frontiers in Behavioral Neuroscience·Qiang ShenRichard P Ebstein
May 14, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jennifer S RichardsJan K Buitelaar
Nov 12, 2016·Neuroscience and Biobehavioral Reviews·Floriana MogaveroJeffrey C Glennon
Dec 17, 2016·Brain Imaging and Behavior·Natàlia Vilor-TejedorJuan R González
Feb 23, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sören MerkerKlaus-Peter Lesch
Feb 6, 2017·Neuroscience and Biobehavioral Reviews·Marieke KleinBarbara Franke
Nov 8, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas Del'GuidiceJean-Martin Beaulieu
Mar 10, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Stefan JohanssonJan Haavik
Feb 7, 2019·Behavioural Pharmacology·Simona CabibStefano Puglisi Allegra
Mar 17, 2011·European Archives of Psychiatry and Clinical Neuroscience·Oussama Kebir, Ridha Joober
Mar 23, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jukka M LeppänenTerho Lehtimäki
May 8, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Bram SizooRutger Jan van der Gaag
Aug 24, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ashley P KennedyClinton D Kilts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.